Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People's Republic of China.
Department of Dentistry, Zhejiang Hospital, Hangzhou 310013, People's Republic of China.
Clin Interv Aging. 2020 Mar 4;15:313-320. doi: 10.2147/CIA.S243211. eCollection 2020.
The study aimed to investigate the association between body composition and frailty in elder inpatients.
This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and March 2019. Sociodemographic, health-related data and anthropometric measurements were evaluated. Body composition was assessed by bioimpedance analysis (BIA), mainly including skeletal muscle mass, body fat mass, total body water, fat-free mass,percent body fat, basal metabolic rate. Frailty was assessed by Clinical Frailty Scale (CFS). Univariate logistic regression was used to analyze the association between body composition and frailty.
Frailty was present in 43.9% of the participants. Frail inpatients showed higher waist circumference, body fat mass and percent body fat, non-frail inpatients showed greater upper arm circumference, calf circumference, skeletal muscle mass, total body water, fat-free mass and basal metabolic rate. Subjects with underweight (body mass index (BMI)<18.5 kg/m; odds ratio (OR), 95% confidence interval (CI)=4.146 (1.286-13.368) P=0.017) and those with high waist circumference (OR 95% CI=1.428 (0.584-3.491) P<0.001), body fat mass (OR, 95% CI=1.143 (0.892-1.315) P<0.001) presented a higher risk of frailty compared to normal subjects. Skeletal muscle mass (OR; 95% CI=0.159 (0.064-0.396) P<0.001) was a protective factor for frailty.
Frailty in elder Chinese inpatients was characterized by a body composition phenotype with underweight, high waist circumference, low skeletal muscle mass and high body fat mass. Underweight, abdominal obesity and sarcopenic obesity may, therefore, be targets for intervention of frailty.
本研究旨在探讨老年住院患者的身体成分与虚弱之间的关系。
这是一项横断面研究，纳入了 2018 年 1 月至 2019 年 3 月期间在浙江医院老年医学科住院的 656 名≥65 岁的老年患者（女性 275 名，男性 381 名）。评估了患者的社会人口学、健康相关数据和人体测量学指标。使用生物电阻抗分析（BIA）评估身体成分，主要包括骨骼肌质量、体脂肪量、总水量、去脂体重、体脂肪百分比、基础代谢率。使用临床虚弱量表（CFS）评估虚弱。使用单因素逻辑回归分析身体成分与虚弱之间的关系。
43.9%的参与者存在虚弱。虚弱的住院患者腰围、体脂肪量和体脂肪百分比较高，而非虚弱的住院患者上臂围、小腿围、骨骼肌质量、总水量、去脂体重和基础代谢率较大。与正常体重的患者相比，体重指数（BMI）<18.5 kg/m²的消瘦患者（优势比[OR]，95%置信区间[CI]：4.146（1.286-13.368），P=0.017）和腰围较高的患者（OR 95% CI：1.428（0.584-3.491），P<0.001）和体脂肪量较高的患者（OR，95% CI：1.143（0.892-1.315），P<0.001）发生虚弱的风险更高。骨骼肌质量（OR；95% CI：0.159（0.064-0.396），P<0.001）是虚弱的保护因素。
中国老年住院患者的虚弱表现为一种以体重不足、高腰围、低骨骼肌质量和高体脂肪量为特征的身体成分表型。因此，体重不足、腹部肥胖和肌少性肥胖可能是虚弱干预的靶点。
