Xu Jie, Sun Min, Chen Meng, Lin Zan, Hu Yong, Luo Xiaobing
Department of Sports Medicine, Sichuan Provincial Orthopedics Hospital, Chengdu, China.
Department of Knee Sports Injury, Sichuan Provincial Orthopedics Hospital, Chengdu, China.
Front Nutr. 2025 Mar 10;12:1534464. doi: 10.3389/fnut.2025.1534464. eCollection 2025.
This study used NHANES data from 2007 to 2018 to examine the relationship between frailty and the Body Roundness Index (BRI) in U.S. people 60 years of age and older. BRI = 364.2-365.5 × sqrt [1-(wc/2π)/(Height/2)]. The degree of frailty was assessed by the frailty index (≥ 0.25). The relationship between frailty and BRI was examined using weighted multivariate logistic regression. To account for potential non-linear patterns, generalized additive modeling (GAM) was utilized, and the ability of BRI to predict frailty was assessed using receiver operating characteristic (ROC) analysis. Results showed that BRI was significantly and positively associated with prevalence of frailty, with a 34% increase in prevalence of frailty per unit increase in a fully adjusted model (OR: 1.34, 95% CI: 1.28, 1.40; < 0.0001). The GAM model showed a significant nonlinear relationship and threshold effect. This study indicates that a higher BRI is closely linked to the onset of frailty in older adults, although additional confirmation through large-scale prospective studies is required.
本研究使用了2007年至2018年的美国国家健康与营养检查调查（NHANES）数据，以检验60岁及以上美国人群中衰弱与身体圆润度指数（BRI）之间的关系。BRI = 364.2 - 365.5×√[1 - (腰围/2π)/(身高/2)]。通过衰弱指数（≥0.25）评估衰弱程度。使用加权多变量逻辑回归分析衰弱与BRI之间的关系。为了考虑潜在的非线性模式，采用了广义相加模型（GAM），并使用受试者工作特征（ROC）分析评估BRI预测衰弱的能力。结果显示，BRI与衰弱患病率显著正相关，在完全调整模型中，每单位增加，衰弱患病率增加34%（比值比：1.34，95%置信区间：1.28，1.40；P < 0.0001）。GAM模型显示出显著的非线性关系和阈值效应。本研究表明，较高的BRI与老年人衰弱的发生密切相关，不过仍需要通过大规模前瞻性研究进行进一步证实。
