Chen Meijie, Chen Jie, Xu Xitong, Qiao Fangwei, Wang Xue, Ji Shaozhen, Gu Zhuqin, Chhetri Jagadish K, Chan Piu
Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Clinical Center for Parkinson's Disease, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Front Neurol. 2020 Feb 28;11:109. doi: 10.3389/fneur.2020.00109. eCollection 2020.
To investigate the relationship between probable rapid eye movement (REM) sleep behavior disorder (pRBD) and cognitive/motor impairments in a community-dwelling population and explore the moderating effects of education. In this cross-sectional study of the Beijing Longitudinal Study of Aging II (BLSA II), 4,477 subjects (≥55 years) fulfilled the inclusion criteria. pRBD was determined by the RBD Questionnaire-Hong Kong (RBDQ-HK). Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used to test the global cognitive performance. Walking speed was used to measure motor function. Logistic regression was performed to assess the relationship between pRBD and cognitive/motor impairments and the moderating effects of education. There were 147 participants (3.3%) with pRBD. Participants with pRBD showed increased risks for cognitive impairment [odds ratio (OR) = 1.88, 95% CI 1.24-2.85, = 0.003], decreased gait speed (OR = 1.43, 95% CI 1.02-2.01, = 0.03), but not for mild cognitive impairment (MCI) (measured by MoCA: OR = 1.01, 95% CI 0.68-1.50, = 0.95; measured by MMSE: OR = 0.90, 95% CI 0.59-1.37, = 0.62). Education modified the effect of pRBD on MCI (measured by MoCA: < 0.001; measured by MMSE: = 0.061) and gait speed ( = 0.008). Our findings suggest that pRBD increases the risk of cognitive/motor impairments for a community-dwelling older population, and education could alleviate the negative effects. These findings implicate that education may have beneficial effects on delaying the onset of cognitive/motor decline in pRBD subjects.
旨在研究社区居住人群中可能的快速眼动（REM）睡眠行为障碍（pRBD）与认知/运动障碍之间的关系，并探讨教育程度的调节作用。在这项针对北京老年纵向研究II（BLSA II）的横断面研究中，4477名受试者（≥55岁）符合纳入标准。pRBD通过香港RBD问卷（RBDQ-HK）进行判定。简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MoCA）用于测试整体认知表现。步行速度用于衡量运动功能。采用逻辑回归分析来评估pRBD与认知/运动障碍之间的关系以及教育程度的调节作用。共有147名参与者（3.3%）患有pRBD。患有pRBD的参与者出现认知障碍的风险增加[比值比（OR）=1.88，95%置信区间1.24-2.85，P=0.003]，步态速度降低（OR=1.43，95%置信区间1.02-2.01，P=0.03），但轻度认知障碍（MCI）风险未增加（通过MoCA测量：OR=1.01，95%置信区间0.68-1.50，P=0.95；通过MMSE测量：OR=0.90，95%置信区间0.59-1.37，P=0.62）。教育程度改变了pRBD对MCI（通过MoCA测量：P<0.001；通过MMSE测量：P=0.061）和步态速度（P=0.008）的影响。我们的研究结果表明，pRBD会增加社区居住老年人群认知/运动障碍的风险，而教育程度可以减轻负面影响。这些发现意味着教育可能对延缓pRBD受试者认知/运动衰退的发生具有有益作用。
