Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Sleep Med. 2017 Feb;30:71-76. doi: 10.1016/j.sleep.2016.06.027. Epub 2016 Nov 21.
To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai.
Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire. We used logistic regression to investigate the associations between these studied factors and pRBD after adjusting for age, sex and other studied factors.
Based on the RBDSQ score ≥5, 2.70% (3.28% in men and 2.41% in women) participants were considered as pRBD. We found that lower education, presence of head injury, atrial fibrillation, hyperlipidemia, constipation, olfactory disturbance, and imbalance, use of alcoholic beverage, selective serotonin reuptake inhibitor, and benzodiazepine were associated with higher likelihood of having pRBD (P < 0.05 for all). In contrast, male sex, use of coffee or tea, smoking and other factors were not significantly association with altered risk of having pRBD. We did not find significant interaction between sex, age and these factors, in relation to pRBD risk.
In this community-based study of older adults, we identified several potential risk factors for concurrent pRBD, including environmental factors and vascular risk factors.
在上海的社区队列中，横断面对 REM 睡眠行为障碍（RBD）的潜在危险因素进行探讨。
基于已验证的 RBD 筛查问卷（RBDSQ），我们在来自上海城市社区的 3635 名（年龄≥50 岁）社区居民中确定了可能患有 RBD（pRBD）的个体。通过问卷评估了可能与 pRBD 相关的潜在危险因素，包括年龄、性别、吸烟、社会经济状况、肥胖、茶（咖啡因摄入的替代物）和酒精的摄入、药物使用和慢性病状况等。我们使用逻辑回归来调查这些研究因素与 pRBD 之间的关联，同时调整了年龄、性别和其他研究因素。
基于 RBDSQ 评分≥5，2.70%（男性为 3.28%，女性为 2.41%）的参与者被认为患有 pRBD。我们发现，较低的教育程度、头部受伤、心房颤动、高血脂、便秘、嗅觉障碍和平衡障碍、饮酒、选择性 5-羟色胺再摄取抑制剂和苯二氮䓬类药物的使用与 pRBD 发生的可能性更高相关（所有因素 P<0.05）。相比之下，男性性别、咖啡或茶的使用、吸烟和其他因素与改变患有 pRBD 的风险没有显著关联。我们没有发现性别、年龄和这些因素之间存在显著的交互作用，与 pRBD 的风险无关。
在这项针对老年人的社区基础研究中，我们确定了几个与同时发生的 pRBD 相关的潜在危险因素，包括环境因素和血管危险因素。
