Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sleep Med. 2023 Oct;110:99-105. doi: 10.1016/j.sleep.2023.08.007. Epub 2023 Aug 6.
To investigate the risk factors for REM sleep behavior disorder (RBD) in a case-control study.
Participants with probable RBD (pRBD) were defined using the RBD Questionnaire-Hong Kong (RBDQ-HK). Controls were collected by matching age and sex. Demographic information, lifestyle, comorbidity, prodromal symptoms of Parkinson's disease (PD), and blood biomarkers were assessed. The associations between these factors and pRBD were investigated by logistic regression. Partial correlation analysis was used to assess the association between the severity of RBD and depression.
A total of 278 pRBD participants (age = 58.31 ± 15.82 years) and 556 controls (age = 58.16 ± 15.84 years) were enrolled in this study. Patients with pRBD were more likely to be current alcohol drinkers (OR 1.50, 95% CI 1.0-2.32). Participants with pRBD had a higher Hamilton Depression Rating Scale (HAMD-17) score (OR 1.17, 95% CI 1.11-1.22) than controls and were more likely to report arthritis (OR 1.53, 95% CI 1.08-2.16), constipation (OR 1.93, 95% CI 1.31-2.86), hyposmia (OR 1.71, 95% CI 1.10-2.67), and depression (OR 3.15, 95% CI 2.17-4.58). Higher levels of total cholesterol (OR 1.15, 95% CI 0.99-1.33) and low-density lipoprotein (OR 1.21, 95% CI 0.99-1.47) had borderline associations with pRBD. Additionally, the severity of pRBD was positively related to depression (r = 0.31, P < 0.01).
We determined several risk factors for pRBD in this case-control study. Future studies are needed to understand the mechanism underlying the association between these factors and pRBD.
在病例对照研究中探究 REM 睡眠行为障碍（RBD）的风险因素。
使用香港 RBD 问卷（RBDQ-HK）对可能患有 RBD（pRBD）的患者进行定义。对照组通过年龄和性别匹配进行收集。评估人口统计学信息、生活方式、合并症、帕金森病（PD）前驱症状和血液生物标志物。通过 logistic 回归分析这些因素与 pRBD 之间的关联。采用偏相关分析评估 RBD 严重程度与抑郁之间的关系。
本研究共纳入 278 例 pRBD 患者（年龄=58.31±15.82 岁）和 556 例对照组（年龄=58.16±15.84 岁）。pRBD 患者更有可能是当前饮酒者（OR 1.50，95%CI 1.0-2.32）。与对照组相比，pRBD 患者的 Hamilton 抑郁量表（HAMD-17）评分更高（OR 1.17，95%CI 1.11-1.22），更有可能报告关节炎（OR 1.53，95%CI 1.08-2.16）、便秘（OR 1.93，95%CI 1.31-2.86）、嗅觉减退（OR 1.71，95%CI 1.10-2.67）和抑郁（OR 3.15，95%CI 2.17-4.58）。总胆固醇（OR 1.15，95%CI 0.99-1.33）和低密度脂蛋白（OR 1.21，95%CI 0.99-1.47）水平较高与 pRBD 呈边缘关联。此外，pRBD 的严重程度与抑郁呈正相关（r=0.31，P<0.01）。
本病例对照研究确定了 pRBD 的几个风险因素。需要进一步的研究来了解这些因素与 pRBD 之间关联的机制。
