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解郁安神颗粒，一种中药制剂，对大鼠脑卒中后抑郁有影响。

Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats.

作者信息

Du Yuan, Ruan Jian, Zhang Leiming, Fu Fenghua

机构信息

Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai 264005, China.

Yantai Center for Food and Drug Control, Yantai 264000, China.

出版信息

Evid Based Complement Alternat Med. 2020 Feb 23;2020:7469068. doi: 10.1155/2020/7469068. eCollection 2020.

DOI:10.1155/2020/7469068
PMID:32184899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060433/
Abstract

Jieyu Anshen granule (JY) is a traditional Chinese medicine formula for treating depression and anxiety. The aim of the study was to observe the effects of JY on poststroke depression (PSD) and investigate the underlying mechanism. PSD rat model was developed by middle cerebral artery occlusion following chronic unpredictable mild stress in conjunction with isolation rearing. We performed behavioral tests, Western blot, ELISA, and BrdU/NeuN staining. Treatment with JY showed significant antidepressant effect in open-field and sucrose preference tests, as well as significant improvement in beam-walking, cylinder, grip strength, and water maze tests. In addition, treatment with JY could restore the levels of neurotransmitters and decrease the levels of hormone and inflammation cytokines in serum and brain. Treatment with JY also showed significant regulation in the expression of neurotransmitter receptors and NF-B/IB- signaling in the prefrontal cortex and hippocampus. Moreover, the numbers of newborn neurons in the hippocampus were increased by treatment with JY. Our results suggest that JY could ameliorate PSD and improve the neurological and cognitive functions. The antidepressive effect may be associated with the modulation of JY on monoamine system, neuroendocrine, neuroinflammation, and neurogenesis.

摘要

解郁安神颗粒（JY）是一种用于治疗抑郁和焦虑的中药配方。本研究旨在观察JY对脑卒中后抑郁（PSD）的影响，并探讨其潜在机制。PSD大鼠模型通过大脑中动脉闭塞联合慢性不可预测轻度应激及隔离饲养建立。我们进行了行为测试、蛋白质免疫印迹法、酶联免疫吸附测定和5-溴脱氧尿嘧啶核苷/神经元核抗原（BrdU/NeuN）染色。JY治疗在旷场试验和蔗糖偏好试验中显示出显著的抗抑郁作用，在横梁行走试验、圆筒试验、握力试验和水迷宫试验中也有显著改善。此外，JY治疗可恢复神经递质水平，降低血清和脑中激素及炎症细胞因子水平。JY治疗还对前额叶皮质和海马中神经递质受体的表达以及核因子-κB/抑制蛋白B信号通路有显著调节作用。而且，JY治疗可增加海马中新生神经元的数量。我们的结果表明，JY可改善PSD并改善神经和认知功能。其抗抑郁作用可能与JY对单胺系统、神经内分泌、神经炎症和神经发生的调节有关。

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