131序列型菌株中整合子及抗菌药物耐药性的特征分析
Characterization of Integrons and Antimicrobial Resistance in Sequence Type 131 Isolates.
作者信息
Huang Jiangqing, Lan Fangjun, Lu Yanfang, Li Bin
机构信息
Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
出版信息
Can J Infect Dis Med Microbiol. 2020 Feb 24;2020:3826186. doi: 10.1155/2020/3826186. eCollection 2020.
BACKGROUND
sequence type 131 (ST131) is an important multidrug-resistant extraintestinal pathogen, which can cause many kinds of infections. Integrons may play a crucial role in the dissemination of antibiotic resistance genes. The purpose of this study was to characterize the prevelance of integrons among ST131 strains in China.
METHODS
Eighty-three ST131 strains in China. ST131 strains in China.
RESULTS
Overall, 26.5% (22/83) of the ST131 strains in China. and ('). Only one type of Pc promoter variant was detected among 22 integron-positive isolates (PcW). In vivo transfer of integron was successful for 9 of integron-positive ST131 strains in China. ST131 strains in China.
CONCLUSIONS
Our study showed a low prevalence of integrons was detected in ST131. Continued surveillance of this mobile genetic element should be performed to study the evolution of antibiotic resistance among ST131. ST131 strains in China. ST131 strains in China.
背景
序列类型131（ST131）是一种重要的耐多药肠外病原体，可引起多种感染。整合子可能在抗生素耐药基因的传播中起关键作用。本研究的目的是确定中国ST131菌株中整合子的流行情况。
方法
中国的83株ST131菌株。中国的ST131菌株。
结果
总体而言，中国26.5%（22/83）的ST131菌株。以及（'）。在22株整合子阳性分离株中仅检测到一种Pc启动子变体（PcW）。中国9株整合子阳性ST131菌株的整合子体内转移成功。中国的ST131菌株。中国的ST131菌株。
结论
我们的研究表明，在ST131中检测到的整合子流行率较低。应持续监测这种移动遗传元件，以研究中国ST131菌株中抗生素耐药性的演变。中国的ST131菌株。中国的ST131菌株。
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