Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi. N. D.) Section of Radiological Sciences, University of Palermo, Palermo, Italy.
Biomed Res Int. 2020 Feb 27;2020:5309307. doi: 10.1155/2020/5309307. eCollection 2020.
To analyze the main etiological factors and some clinical features of patients with hepatocellular carcinoma (HCC) at diagnosis and to compare them with those we described ten years ago. . We compared two groups of patients with HCC, Group 1 consisting of 132 patients (82 M, 50 F) diagnosed in the 2003-2008 period and Group 2 including 119 patients (82 M, 37 F) diagnosed in the 2013-2018 period. For all patients, age, sex, viral markers, alcohol consumption, serum alpha-fetoprotein (AFP) levels, and the main liver function parameters were recorded. The diagnosis of HCC was based on AASLD, EASL guidelines. The staging was classified according to the "Barcelona Clinic Liver Cancer staging system" (BCLC).
Mean age was 69.0 ± 8 years in Group 1 and 71.0 ± 9 in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 ( < 0.05). HCV subjects were significantly older in Group 2 (.
This study shows that over the last decade a number of features of patients with HCC in our region have changed, particularly age at onset, etiological factors, and staging of HCC.
分析初诊肝细胞癌（HCC）患者的主要病因学因素和部分临床特征，并与我们十年前描述的情况进行比较。我们比较了两组 HCC 患者，第 1 组包括 132 例患者（82 例男性，50 例女性），诊断时间为 2003 年至 2008 年；第 2 组包括 119 例患者（82 例男性，37 例女性），诊断时间为 2013 年至 2018 年。所有患者均记录年龄、性别、病毒标志物、饮酒、血清甲胎蛋白（AFP）水平和主要肝功能参数。HCC 的诊断依据美国肝病研究学会（AASLD）和欧洲肝脏研究学会（EASL）指南。分期根据“巴塞罗那临床肝癌分期系统”（BCLC）进行分类。
第 1 组的平均年龄为 69.0±8 岁，第 2 组为 71.0±9 岁（<0.05）。第 2 组 HCV 患者年龄明显较大（<0.05）。第 2 组 HCV 患者年龄明显较大（<0.05）。第 2 组 HCV 患者年龄明显较大（<0.05）。第 2 组 HCV 患者年龄明显较大（<0.05）。
本研究表明，在过去十年中，我们地区 HCC 患者的一些特征发生了变化，特别是发病年龄、病因和 HCC 分期。
