Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Biomed Res Int. 2020 Feb 24;2020:9705950. doi: 10.1155/2020/9705950. eCollection 2020.
Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life. However, the molecular characterization of each rosacea subtype is still unclear. Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder. In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses using Gene Onotology, KEGG, GSEA, and WGCNA. Compared to the control group, 13 differentially expressed lncRNAs and 525 differentially expressed mRNAs were identified in the three rosacea subtypes. The differentially expressed genes identified were enriched in four signaling pathways and the GO terms found were associated with leukocyte migration. In addition, we found nine differentially expressed lncRNAs in all three rosacea subtype-related networks, including NEAT1 and HOTAIR, which may play important roles in the pathology of rosacea. Our study provided novel insights into lncRNA-mRNA coexpression networks to discover the molecular mechanisms involved in rosacea development that can be used as future targets of rosacea diagnosis, prevention, and treatment.
酒渣鼻是一种慢性、复发性炎症性皮肤疾病，全球发病率差异较大，严重影响患者的健康和生活质量。然而，每种酒渣鼻亚型的分子特征尚不清楚。此外，关于长链非编码 RNA（lncRNA）在该疾病发病机制或调控过程中的作用知之甚少。本研究我们建立了三种酒渣鼻亚型（红斑毛细血管扩张型、丘疹脓疱型和鼻赘型）的 lncRNA-mRNA 共表达网络，并使用 Gene Ontology、KEGG、GSEA 和 WGCNA 进行了功能富集分析。与对照组相比，三种酒渣鼻亚型中共鉴定出 13 个差异表达的 lncRNA 和 525 个差异表达的 mRNA。鉴定出的差异表达基因富集在四个信号通路中，GO 术语与白细胞迁移有关。此外，我们在所有三种酒渣鼻亚型相关网络中发现了 9 个差异表达的 lncRNA，包括 NEAT1 和 HOTAIR，它们可能在酒渣鼻发病机制中发挥重要作用。本研究为 lncRNA-mRNA 共表达网络提供了新的见解，以发现参与酒渣鼻发展的分子机制，可作为酒渣鼻诊断、预防和治疗的未来靶点。
