Ntali Stella, Pantazi Lamprini, Mpoki Kyriaki, Nikolopoulos Dionysios, Fanouriakis Antonis, Kallitsakis Ioannis, Papagoras Charalambos, Dimopoulou Despoina, Kteniadaki Eleni, Emmanouilidou Evgenia, Chania Vassiliki, Bertsias George
Private Practice Rheumatologist, Thessaloniki, Greece.
Rheumatology Unit, GHA, Sismanogleio, Athens, Greece.
Mediterr J Rheumatol. 2018 Dec 18;29(4):228-231. doi: 10.31138/mjr.29.4.228. eCollection 2018 Dec.
Pregnancy in women with SLE (Systematic Lupus Erythematosus) is considered of "high risk" since it has been related with adverse events both in the mother and the foetus. Many studies have reported relapse of the disease during the pregnancy and the first trimester post-labour, while others have found no difference in terms of frequency and type of relapses. Moreover, adverse obstetrical events like recurrent pregnancy loss, preeclampsia, prematurity, intrauterine growth restriction and neonatal lupus syndrome tend to occur more often in patents with SLE. However, most of these data regarding the burden and pregnancy outcomes in SLE come from retrospective studies of previous decades, and in non-Caucasian patients. To this end, more recent studies have suggested overall improved outcomes of pregnancy, still their results are often conflicting. The purpose of this study is to record, through a prospective observational (non-interventional) study, the contemporary prognosis of pregnancy in women with SLE who are followed-up by private and hospital physicians in Greece. In particular, we aim to establish a registry to study the course of the disease during pregnancy, the outcome of pregnancy and the possible negative or positive prognostic factors, the effect of drugs on pregnancy and the foetus.
系统性红斑狼疮（SLE）女性的妊娠被视为“高危”妊娠，因为其与母体和胎儿的不良事件均有关联。许多研究报告了疾病在孕期及产后头三个月复发的情况，而其他研究则发现复发频率和类型并无差异。此外，复发性流产、子痫前期、早产、胎儿生长受限和新生儿狼疮综合征等不良产科事件在SLE患者中往往更常发生。然而，大多数关于SLE患者负担和妊娠结局的数据来自过去几十年的回顾性研究，且研究对象为非白种人患者。为此，最近的研究表明妊娠总体结局有所改善，但结果往往相互矛盾。本研究的目的是通过一项前瞻性观察性（非干预性）研究，记录希腊私立和医院医生随访的SLE女性妊娠的当代预后情况。具体而言，我们旨在建立一个登记系统，以研究疾病在孕期的发展过程、妊娠结局以及可能的阴性或阳性预后因素、药物对妊娠和胎儿的影响。
