Mende Miriam, Borchardt-Lohölter Viola, Meyer Wolfgang, Scheper Thomas, Schlumberger Wolfgang
EUROIMMUN AG, Luebeck, Germany.
Mediterr J Rheumatol. 2019 Sep 30;30(3):155-161. doi: 10.31138/mjr.30.3.155. eCollection 2019 Sep.
Myopathies are a rare type of acquired, chronic autoimmune diseases of the skeletal muscles and affect both children and adults. The hallmark symptoms of idiopathic inflammatory myopathies (IIM) are muscle inflammation, proximal muscle weakness and disability, arthritis, cutaneous rashes, calcinosis, ulceration, malignancy and interstitial lung disease (ILD). Subforms of IIM include polymyositis, dermatomyositis, cancer-related myositis and sporadic inclusion body myositis. Autoantibodies function as biomarkers for diagnosis of IIM and can be used to delimit clinically distinguishable IIM subforms. To maximise the diagnostic information it is essential to perform comprehensive multiparametric serological testing including both screening and confirmation tests.
肌病是一种罕见的后天性慢性骨骼肌自身免疫性疾病，可影响儿童和成人。特发性炎性肌病（IIM）的标志性症状包括肌肉炎症、近端肌无力和功能障碍、关节炎、皮疹、钙质沉着、溃疡、恶性肿瘤和间质性肺病（ILD）。IIM的亚型包括多发性肌炎、皮肌炎、癌症相关性肌炎和散发性包涵体肌炎。自身抗体作为IIM诊断的生物标志物，可用于界定临床上可区分的IIM亚型。为了最大化诊断信息，进行包括筛查和确认试验在内的全面多参数血清学检测至关重要。
