Bentivoglio P, Branston N M, Mayberg M, Habib A H, Symon L
Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, U.K.
Acta Neurochir (Wien). 1988;95(1-2):61-71. doi: 10.1007/BF01793085.
The effects of acute proximal basilar artery occlusion on blood flow, autoregulation and CO2 reactivity in four separate regions of the brain (cerebral cortex, thalamus, brainstem and caudal pons) were studied and compared in 30 anaesthetised baboons. Significant flow changes were seen in all areas of the basilar territory, even in instances where the posterior communicating artery was observed to be relatively large. Flow changes were also seen in regions of the brain remote from the basilar territory. Areas furthest from the collateral blood supply showed the largest changes in blood flow, as has previously been shown in the case of proximal middle cerebral artery occlusion. From this, one can predict that in surgery, the more rostral the occlusion of the artery, the safer the procedure should be. At normal blood pressure, while the collateral circulation to the brainstem and thalamus was adequate to maintain normal electrical function after basilar occlusion, the flow was totally inadequate to maintain autoregulation or CO2 reactivity in the basilar territory.
在30只麻醉的狒狒中，研究并比较了急性基底动脉近端闭塞对大脑四个不同区域（大脑皮层、丘脑、脑干和脑桥尾端）的血流、自动调节和二氧化碳反应性的影响。在基底动脉供血区域的所有部位均观察到显著的血流变化，即使在后交通动脉相对较大的情况下也是如此。在远离基底动脉供血区域的脑区也观察到了血流变化。与大脑中动脉近端闭塞的情况一样，距离侧支循环最远的区域血流变化最大。由此可以预测，在手术中，动脉闭塞部位越靠上，手术应该越安全。在正常血压下，虽然基底动脉闭塞后脑干和丘脑的侧支循环足以维持正常的电功能，但基底动脉供血区域的血流完全不足以维持自动调节或二氧化碳反应性。
