Dettmers C, Hartmann A, Rommel T, Hartmann S, Pappata S, Baron J C
Neurologische Universitätsklinik, Bonn, Germany.
Neurol Res. 1995 Apr;17(2):109-12. doi: 10.1080/01616412.1995.11740297.
2,3,5-triphenyltetrazoliumchloride (TTC) as an indicator of mitochondrial function in combination with regional cerebral blood flow measurements was used in six baboons 6.9 +/- 1.2 h after permanent occlusion of the left middle cerebral artery. Staining with TTC was compared with blood flow data obtained during normocapnia using the microsphere method. Five animals showed a focal area of unstained tissue in the left middle cerebral artery territory. Mean blood flow in the unstained area was 28.3 +/- 15.4 ml min-1 100 g-1. Five of 6 animals showed a significant decrease of contralateral cerebellar blood flow in the presence of normal TTC staining. We conclude that at this early stage of infarction contralateral cerebellar diaschisis is caused by functional deactivation.
在永久性闭塞左大脑中动脉6.9±1.2小时后，对6只狒狒使用2,3,5 - 三苯基氯化四氮唑（TTC）作为线粒体功能指标并结合局部脑血流量测量。将TTC染色结果与使用微球法在正常碳酸血症期间获得的血流数据进行比较。5只动物在左大脑中动脉区域出现未染色组织的局灶性区域。未染色区域的平均血流量为28.3±15.4毫升·分钟⁻¹·100克⁻¹。6只动物中有5只在TTC染色正常的情况下对侧小脑血流量显著下降。我们得出结论，在梗死的这个早期阶段，对侧小脑交叉性机能缺失是由功能失活引起的。
