吉西他滨/奥沙利铂方案治疗晚期胆道癌中炎症标志物对生存的影响。

The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen.

机构信息

Department of Medical Oncology, Adana City Education and Research Hospital, Adana, Turkey.

Department of Internal Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey.

出版信息

J Gastrointest Cancer. 2021 Mar;52(1):249-255. doi: 10.1007/s12029-020-00396-x.

DOI:10.1007/s12029-020-00396-x

PMID:32185743

Abstract

BACKGROUND

In advanced biliary tract carcinoma (BTC), the prognosis is very poor, and the overall survival is less than 1 year. This study aimed to determine the effect of neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), C-reactive protein (CRP)/albumin ratio (CAR), and prognostic nutritional index (PNI) on the survival of BTC patients treated with gemcitabine/oxaliplatin (GEMOX) regimen.

METHODS

Data of 53 patients with advanced BTC were evaluated retrospectively. Association between inflammatory markers and 6-month PFS and 12-month OS were compared by the log-rank test. The optimal cutoff values were determined by a receiver operating characteristic (ROC) curve analysis. NLR, dNLR, CAR, and PNI were grouped based on cutoff points 1.95, 1.15, 0.57, and 33, respectively. Univariate and multivariate analyses were used to assess their prognostic values for survival.

RESULTS

Lower dNLR (< 1.15) was prognostic for higher 6-month PFS and 12-month OS rates, while lower NLR (< 1.95) was prognostic for higher 6-month PFS rates only. CAR and PNI did not have statistically significant effects on survival.

CONCLUSIONS

Pretreatment dNLR and NLR values in advanced BTC can be used as predictive markers for survival in patients undergoing the GEMOX regimen.

摘要

背景

在晚期胆道癌（BTC）中，预后非常差，总生存期不到 1 年。本研究旨在确定中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、C 反应蛋白/白蛋白比值（CAR）和预后营养指数（PNI）对接受吉西他滨/奥沙利铂（GEMOX）方案治疗的 BTC 患者生存的影响。

方法

回顾性评估了 53 例晚期 BTC 患者的数据。通过对数秩检验比较炎症标志物与 6 个月 PFS 和 12 个月 OS 的相关性。通过接受者操作特征（ROC）曲线分析确定最佳截断值。根据截断值 1.95、1.15、0.57 和 33 将 NLR、dNLR、CAR 和 PNI 分别分组。使用单因素和多因素分析评估它们对生存的预后价值。