First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, China.
Department of Cardiology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China.
J Tradit Chin Med. 2018 Oct;38(5):726-732.
To investigate the effects of tonifying Qi and activating blood circulation (SQABC), a method in Traditional Chinese Medicine (TCM), on end-point events in patients with myocardial infarction (MI) in this retrospective cohort study.
Clinical data were obtained from the medical records of patients with acute MI (AMI), both during hospitalization and follow-up, and included general demographic information (age, gender, and contact information), TCM regimens used, and end-point events.
A total of 1596 patients with AMI were enrolled to this study, but data of only 1210 cases are accessible till follow-up. We classified the patients based on the exposure levels of SQABC. When comparing the results between all exposure and non-exposure groups, significant differences were identified, both during hospitalization and follow-ups. During hospitalization, cardiac death (4.40% vs 21.55%, P < 0.05) and cardiac shock (3.04% vs 11.62%, P < 0.05) were significantly lower in the exposure group than the non-exposure group. Similarly, during the follow-up, cardiac death (12.04% vs 20.49%, P < 0.05), acute heart failure (7.27% vs 11.81%, P < 0.05), composite endpoint of reinfarction and stroke (9.11% vs 15.28%, P < 0.05), and rehospitalization due to angina (25.49% vs 34.38%, P < 0.05) were significantly lower in the exposure group than the non-exposure group.
Our findings suggest that SQABC can significantly benefits the subjects in the management of high-risk AMI in them.
本回顾性队列研究旨在探讨中医补气活血法（SQABC）对心肌梗死（MI）患者终点事件的影响。
从急性 MI（AMI）患者的住院和随访病历中获取临床数据，包括一般人口统计学信息（年龄、性别和联系方式）、使用的中医方剂和终点事件。
本研究共纳入 1596 例 AMI 患者，但随访时仅可获得 1210 例病例的数据。我们根据 SQABC 的暴露水平对患者进行分类。在比较所有暴露组和非暴露组的结果时，无论是在住院期间还是随访期间，均发现存在显著差异。在住院期间，暴露组的心脏性死亡（4.40%比 21.55%，P < 0.05）和心源性休克（3.04%比 11.62%，P < 0.05）发生率明显低于非暴露组。同样，在随访期间，暴露组的心脏性死亡（12.04%比 20.49%，P < 0.05）、急性心力衰竭（7.27%比 11.81%，P < 0.05）、再梗死和脑卒中复合终点（9.11%比 15.28%，P < 0.05）以及因心绞痛再住院（25.49%比 34.38%，P < 0.05）发生率明显低于非暴露组。
我们的研究结果表明，SQABC 可显著改善高危 AMI 患者的预后。
