Chen Yulong, Du Jianxia, Sun Xiao, Li Qiancheng, Qin Ming, Xiao Qian, Bryan Mark
Department of Ultrasound, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.
Department of Emergency, Xuzhou Central Hospital, Xuzhou, China.
JMIR Med Inform. 2020 Sep 16;8(9):e19110. doi: 10.2196/19110.
Cardiac hypertrophy induced by pressure overload is one of the important causes of heart failure and sudden cardiac death. At present, there are few studies on the outcome of left ventricular hypertrophy and left ventricular function after complete pressure load removal.
This study aims to better simulate the changes of left ventricular structure and function during the process of left ventricular pressure overload and deloading, and to explore the application of echocardiography in it.
In this study, healthy male (BALB/C) mice were used as research objects to establish an ascending aorta constriction model, to carry out echocardiographic and hemodynamic examinations, to establish an ascending aorta deconstriction model in mice, and to carry out echocardiographic and hemodynamic examinations.
Compared with the sham operation group, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), interventricular septal (IVS), and left ventricular posterior wall (LVPW) in the constriction operation group were significantly increased (P=.02, P=.02, P=.02, and P=.02, respectively). LVESD, LVEDD, IVS, and LVPW in the early and late constriction groups were significantly decreased, and the degree of decrease in the early group was greater than that in the late group; compared with the sham operation group, left ventricular diastolic pressure in the constriction operation group increased significantly at 9 and 15 weeks after operation (P=.03). Left ventricular systolic pressure at 15 weeks after operation decreased to a certain extent but was higher than that of the sham operation group (P=.02). The maximal rate of the increase of left ventricular pressure at 3 weeks, 9 weeks, and 15 weeks after operation decreased significantly (P=.03, P=.02, and P=.02, respectively).
In this study, the ascending aorta coarctation model and descending aorta coarctation model were successfully established, which verifies the value of echocardiography information data monitoring in the treatment of left ventricular circulation disorders and the evaluation of surgical treatment.
压力超负荷诱导的心肌肥厚是心力衰竭和心源性猝死的重要原因之一。目前，关于完全解除压力负荷后左心室肥厚及左心室功能转归的研究较少。
本研究旨在更好地模拟左心室压力超负荷及解除过程中左心室结构和功能的变化，并探讨超声心动图在其中的应用。
本研究以健康雄性（BALB/C）小鼠为研究对象，建立升主动脉缩窄模型，进行超声心动图及血流动力学检查，再建立小鼠升主动脉解除缩窄模型，并进行超声心动图及血流动力学检查。
与假手术组比较，缩窄手术组左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）、室间隔（IVS）及左心室后壁（LVPW）均显著增加（分别为P = 0.02、P = 0.02、P = 0.02和P = 0.02）。缩窄早期组和晚期组的LVESD、LVEDD、IVS及LVPW均显著减小，且早期组减小程度大于晚期组；与假手术组比较，缩窄手术组术后9周和15周左心室舒张压显著升高（P = 0.03）。术后15周左心室收缩压有一定程度下降，但仍高于假手术组（P = 0.02）。术后3周、9周和15周左心室压力最大上升速率显著降低（分别为P = 0.03、P = 0.02和P = 0.02）。
本研究成功建立了升主动脉缩窄模型和降主动脉缩窄模型，验证了超声心动图信息数据监测在左心室循环障碍治疗及手术治疗评估中的价值。
