Peng Longping, Yao Bing, Hong Zhiwei, Shen Jiaming, Hu Xuechun, Shao Yong, Jing Jun, Lu Jinchun
Center for Reproductive Medicine, Jinling Hospital Affiliated to Southern Medical University, Nanjing 210002, China.
Center for Reproductive Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
J Tradit Chin Med. 2018 Apr;38(2):266-271.
To investigate the effects of Ningmitai capsule combined with sertraline on patients with premature ejaculation (PE) and an increased anterior-posterior diameter (APD) of the seminal vesicles (SVs).
Sixty men with acquired PE were enrolled and randomly divided into two groups. The combined group was treated with Ningmitai capsule and sertraline, while the control group was treated with sertraline alone. Main outcomes were measured using the premature ejaculation diagnostic tool (PEDT), APD of SVs, and Clinical Global Impression of Change questionnaire and compared before and after 3 months of treatment.
Comparing after treatment with before treatment outcomes within each group, the PEDT score was significantly reduced in the combined group (12.1 ¡À 2.5 vs 8.6 ¡À 3.2, P < 0.001, respectively) and control group (12.9 ¡À 2.6 vs 10.3 ¡À 1.6, P < 0.001, respectively). Furthermore, the PEDT score after treatment was significantly lower in the combined compared with control group (8.6 ¡À 3.2 vs 10.3 ¡À 1.6, P = 0.011, respectively). The APD of SVs in the combined group was significantly decreased after treatment [(10.8 ¡À 2.4) vs (12.9 ¡À 2.2) mm, P = 0.001], while the APD of SVs in the control group was equivalent before and after treatment. The treatment response rate was not significantly higher in the combined compared with control group.
These results indicated that the effect of Ningmitai capsule combined with sertraline was better than that of sertraline alone for the treatment of PE patients exhibiting an increased APD of SVs. The therapeutic effect found for the combined treatment may be due to antibacterial and anti-inflammatory activity reported for Ningmitai capsule, and may suggest that seminal vesiculitis is a potential pathophysiological factor in acquired PE.
探讨宁泌泰胶囊联合舍曲林对早泄（PE）患者及精囊前后径（APD）增大患者的影响。
纳入60例获得性PE男性患者，随机分为两组。联合组采用宁泌泰胶囊和舍曲林治疗，而对照组仅采用舍曲林治疗。主要结局指标采用早泄诊断工具（PEDT）、精囊APD及临床总体印象变化问卷进行测量，并在治疗3个月前后进行比较。
比较每组治疗后与治疗前的结局，联合组（分别为12.1±2.5 vs 8.6±3.2，P<0.001）和对照组（分别为12.9±2.6 vs 10.3±1.6，P<0.001）的PEDT评分均显著降低。此外，联合组治疗后的PEDT评分显著低于对照组（分别为8.6±3.2 vs 10.3±1.6，P=0.011）。联合组治疗后精囊APD显著降低[（10.8±2.4） vs （12.9±2.2）mm，P=0.001]，而对照组治疗前后精囊APD相当。联合组的治疗有效率与对照组相比无显著升高。
这些结果表明，对于表现出精囊APD增大的PE患者，宁泌泰胶囊联合舍曲林的疗效优于单独使用舍曲林。联合治疗发现的治疗效果可能归因于宁泌泰胶囊报道的抗菌和抗炎活性，并且可能提示精囊炎是获得性PE的潜在病理生理因素。
