Li Yan, Gu Jianzhong, Zhou Huamiao, Yang Weihong, Guo Yong, Wang Hui, Zou Ying
Department of First Clinical Medicine, Zhejiang Chinese Medicine University, Hangzhou 310053, China.
Department of Oncology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, China.
J Tradit Chin Med. 2018 Apr;38(2):299-308.
To observe the symptom patterns (or syndromes) according to Traditional Chinese Medicine (TCM) theory in patients with various stages of colorectal cancer, and to observe the dynamic evolution process of these TCM patterns.
A prospective and cross-sectional questionnaire-based investigation was performed. Clinical data on TCM symptom patterns in patients with colorectal cancer in the perioperative period (210 cases) and adjuvant treatment period (160 cases) were collected. EPIData 3.1 together with frequency statistics and cluster analyses were performed to identify the TCM patterns based on symptom characteristics in patients with colorectal cancer, and to assess the dynamic changes in these patterns.
In the perioperative period, from the first day of perioperative care to postoperative days 3, 7, and 10, the TCM pattern showed a process of dynamic change from blood deficiency to deficiency of both Qi and Yin and the pattern of dampness and hot accumulative knotting. In the adjuvant treatment period, the TCM pattern changed from Qi deficiency and Yin deficiency inner-heat with dampness to a deficiency pattern, primarily including Yin deficiency of the liver and kidney, deficiency of Qi and blood, and spleen deficiency.
Our study confirmed that variations in the dynamic evolution of TCM symptom patterns exist in patients with colorectal cancer during different treatment periods. This information is of great value in the individualized management of colorectal cancer.
依据中医理论观察结直肠癌不同阶段患者的症状模式（或证型），并观察这些中医证型的动态演变过程。
进行一项基于问卷的前瞻性横断面调查。收集围手术期（210例）和辅助治疗期（160例）结直肠癌患者的中医症状模式临床数据。运用EPIData 3.1软件并结合频率统计和聚类分析，根据结直肠癌患者的症状特征确定中医证型，并评估这些证型的动态变化。
围手术期，从围手术期护理第一天至术后第3天、第7天和第10天，中医证型呈现出从血虚到气阴两虚以及湿热蕴结证型的动态变化过程。辅助治疗期，中医证型从气虚阴亏内热兼湿转变为虚证，主要包括肝肾阴虚、气血亏虚和脾虚。
我们的研究证实，结直肠癌患者在不同治疗阶段存在中医症状模式的动态演变差异。该信息对结直肠癌的个体化管理具有重要价值。
