Department of Paper Technology, Indian Institute of Technology Roorkee, Roorkee, India.
Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, India.
J Biomater Sci Polym Ed. 2020 Jun;31(8):1091-1106. doi: 10.1080/09205063.2020.1740965. Epub 2020 Mar 18.
Cotton is cheap, easily available and widely used as surgical material. Therefore, cotton would be good raw material to design a scaffold for tissue engineering applications. In this work, the gelatin-coated microfibrous paper scaffold was fabricated successfully by a papermaking process. Microfibers-based scaffold could overcome the limitations of nanofibrous material-based scaffold for tissue engineering application. The physicochemical and mechanical properties of the scaffolds were characterized. The results revealed that the gelatin contributed to the enhanced cell attachment and proliferation over the scaffolds, whereas cellulose as a strong backbone in the scaffold to support it for keeping its appearance. Their tensile strength and water absorption capacity were improved, but pore size and porosity were decreased after incorporation of gelatin. Hence, results suggested that fabricated scaffolds have huge prospective as a bioactive, well-designed and economical scaffold stand for tissue engineering application.
棉花价格低廉，易于获得，广泛用作外科手术材料。因此，棉花是设计组织工程应用支架的理想原料。在这项工作中，通过造纸工艺成功制备了明胶涂覆的微纤维纸支架。基于微纤维的支架可以克服基于纳米纤维材料的支架在组织工程应用中的局限性。对支架的理化和机械性能进行了表征。结果表明，明胶有助于增强细胞在支架上的附着和增殖，而纤维素作为支架中的强骨架，支撑着支架，保持其外观。加入明胶后，支架的拉伸强度和吸水率得到提高，而孔径和孔隙率降低。因此，结果表明，所制备的支架具有作为生物活性、设计良好且经济的组织工程应用支架的巨大潜力。
