Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine.
Division of Nephrology and Kidney Institute.
QJM. 2020 Sep 1;113(9):643-650. doi: 10.1093/qjmed/hcaa096.
Air pollution had been reported to be associated with the reproductive health of women. However, the association of particulate matter (PM) and acid gases air pollution with premenstrual syndrome (PMS) warrants investigation. This study investigated the effects of air pollution on PMS risk.
We combined data from the Taiwan Air Quality-Monitoring Database and the Longitudinal Health Insurance Database. In total, an observational cohort of 85 078 Taiwanese women not diagnosed as having PMS.
Air pollutant concentrations were grouped into four levels based on the concentration quartiles of several types of air pollutants.
We then applied univariable and multivariable Cox proportional hazard regression models to assess PMS risk in association with each pollutant type.
Women exposed to Q4-level SO2 exhibited a 7.77 times higher PMS risk compared with those to Q1-level SO2 (95% confidence interval [CI] = 6.22-9.71). Women exposed to Q4-level NOx exhibited a 2.86 times higher PMS risk compared with those exposed to Q1-level NOx (95% CI = 2.39-3.43). Women exposed to Q4-level NO exhibited a 3.17 times higher PMS risk compared with women exposed to Q1-level NO (95% CI = 2.68-3.75). Finally, women exposed to Q4-level PM with a ≤2.5-µm diameter (PM2.5) exhibited a 3.41 times higher PMS risk compared with those exposed to Q1-level PM2.5 (95% CI = 2.88-4.04).
High incidences of PMS were noted in women who lived in areas with higher concentrations of SO2, NOx, NO, NO2 and PM2.5.
已有研究报道，空气污染与女性生殖健康有关。然而，颗粒物（PM）和酸性气体空气污染与经前期综合征（PMS）之间的关联仍需进一步研究。本研究旨在探讨空气污染对 PMS 风险的影响。
我们结合了来自台湾空气质量监测数据库和纵向健康保险数据库的数据。共纳入了 85078 名未被诊断为 PMS 的台湾女性的观察性队列。
根据几种空气污染物浓度的四分位数，将空气污染物浓度分为四个水平。
然后，我们应用单变量和多变量 Cox 比例风险回归模型来评估与每种污染物类型相关的 PMS 风险。
与 Q1 水平 SO2 暴露的女性相比，暴露于 Q4 水平 SO2 的女性 PMS 风险高出 7.77 倍（95%置信区间[CI]：6.22-9.71）。与 Q1 水平 NOx 暴露的女性相比，暴露于 Q4 水平 NOx 的女性 PMS 风险高出 2.86 倍（95% CI：2.39-3.43）。与 Q1 水平 NO 暴露的女性相比，暴露于 Q4 水平 NO 的女性 PMS 风险高出 3.17 倍（95% CI：2.68-3.75）。最后，与暴露于 Q1 水平 PM2.5 的女性相比，暴露于 Q4 水平 PM2.5（直径≤2.5μm）的女性 PMS 风险高出 3.41 倍（95% CI：2.88-4.04）。
在居住在 SO2、NOx、NO、NO2 和 PM2.5 浓度较高地区的女性中，PMS 的发病率较高。
