Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, 404 Taichung, Taiwan.
Division of Nephrology and Kidney Institute, China Medical University Hospital, 404 Taichung, Taiwan.
Int J Environ Res Public Health. 2018 Dec 14;15(12):2860. doi: 10.3390/ijerph15122860.
: Air pollution has been associated with autoimmune diseases. Nephrotic syndrome is a clinical manifestation of immune-mediated glomerulopathy. However, the association between nephrotic syndrome and air pollution constituents remains unknown. We conducted this nationwide retrospective study to investigate the association between PM and nephrotic syndrome. : We used the Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality-Monitoring Database (TAQMD). We combined and stratified the LHID and the TAQMD data by residential areas of insurants linked to nearby air quality-monitoring stations. Air pollutant concentrations were grouped into four levels based on quartile. Univariable and multivariable Cox proportional hazard regression models were applied. : Relative to Q1-level SO₂, subjects exposed to the Q4 level were associated with a 2.00-fold higher risk of nephrotic syndrome (adjusted HR = 2.00, 95% CI = 1.66⁻2.41). In NOx, relative to Q1 NOx concentrations, the adjusted HRs of nephrotic syndrome risk were 1.53 (95% CI = 1.23⁻1.91), 1.30 (95% CI = 1.03⁻1.65), and 2.08 (95% CI = 1.69⁻2.56) for Q2, Q3, and Q4 levels, respectively. The results revealed an increasing trend for nephrotic syndrome risk correlating with increasing levels of NO, NO₂, and PM concentrations. : High concentrations of PM, NO, NO₂, and SO₂ are associated with increased risk of nephrotic syndrome.
空气污染与自身免疫性疾病有关。肾病综合征是免疫介导的肾小球疾病的一种临床表现。然而，肾病综合征与空气污染成分之间的关联尚不清楚。我们进行了这项全国性的回顾性研究，以调查 PM 与肾病综合征之间的关系。
我们使用了纵向健康保险数据库（LHID）和台湾空气质量监测数据库（TAQMD）。我们将 LHID 和 TAQMD 数据按与附近空气质量监测站相关的被保险人的居住区域进行了组合和分层。根据四分位数将空气污染物浓度分为四个水平。应用单变量和多变量 Cox 比例风险回归模型。
与 Q1 水平的 SO₂相比，暴露于 Q4 水平的人群患肾病综合征的风险高出 2.00 倍（调整后的 HR = 2.00，95%CI = 1.66⁻2.41）。在 NOx 中，与 Q1 NOx 浓度相比，肾病综合征风险的调整后 HRs 分别为 1.53（95%CI = 1.23⁻1.91）、1.30（95%CI = 1.03⁻1.65）和 2.08（95%CI = 1.69⁻2.56），适用于 Q2、Q3 和 Q4 水平。结果显示，肾病综合征风险与 PM、NO、NO₂和 SO₂浓度的升高呈正相关。
高浓度的 PM、NO、NO₂和 SO₂与肾病综合征风险的增加相关。
