Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Department of Anesthesiology, First Clinical Medical College, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Mol Med Rep. 2020 May;21(5):2019-2029. doi: 10.3892/mmr.2020.11017. Epub 2020 Mar 10.
Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G‑CSF plays an important role in cancer progression. G‑CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G‑CSF has an adverse effect. The current review provides an overview of G‑CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.
粒细胞集落刺激因子（G-CSF）是造血生长因子家族的一员，主要影响中性粒细胞谱系。G-CSF 是外周血干细胞的强大动员剂，重组人 G-CSF（rhG-CSF）已被用于治疗癌症患者化疗后的粒细胞减少症和中性粒细胞减少症。然而，最近的研究发现 G-CSF 在癌症进展中起着重要作用。不同类型的癌细胞（如肺癌、胃癌、结直肠癌、浸润性膀胱癌、神经胶质瘤和乳腺癌）中 G-CSF 的表达增加。然而，尚不清楚 G-CSF 治疗是否有不良影响。本综述概述了 G-CSF 在恶性乳腺癌发展中的作用，本综述中提供的数据有望为癌症治疗提供新的思路。
