Schäfer Viola, Weitzel Karl-Michael
Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein Strasse, 35043 Marburg, Germany.
Anal Chem. 2020 Apr 7;92(7):5492-5499. doi: 10.1021/acs.analchem.0c00234. Epub 2020 Mar 18.
Femtosecond-laser ionization mass spectrometry (fs-LIMS) is demonstrated to be a powerful analytical method providing access to the qualitative distinction of structural isomers of -, -, and -fluorotoluene. The key point of the approach presented is a systematic variation of the spectral phase of the fs-laser pulses, which characteristically affects the fragmentation pattern observed in the mass spectra. Variation of the linear chirp parameter is also helpful for rationalizing the fragmentation mechanism. Ultimately two ternary mixtures of the three title isomers are quantitatively analyzed in situ with an accuracy of 5% for the molar fractions.
飞秒激光电离质谱法（fs-LIMS）被证明是一种强大的分析方法，可用于对邻氟甲苯、间氟甲苯和对氟甲苯的结构异构体进行定性区分。本文所提出方法的关键在于飞秒激光脉冲光谱相位的系统变化，这会显著影响质谱中观察到的碎片模式。线性啁啾参数的变化也有助于阐明碎片形成机制。最终，对三种标题异构体的两种三元混合物进行了原位定量分析，摩尔分数的准确度为5%。
