Fachbereich Chemie, Philipps-Universität Marburg, 35032, Marburg, Germany.
Angew Chem Int Ed Engl. 2021 Aug 9;60(33):17861-17865. doi: 10.1002/anie.202107150. Epub 2021 Jul 8.
The chirality of chemical compounds is of undisputed importance in science and technology. In particular with respect to pharmacological application most molecules of interest cannot be accessed by the powerful techniques developed in recent years for gas phase analytes. Here, we demonstrate that the combination of electrospray ionization (ESI) with the detection of photoelectron circular dichroism (PECD) provides access to chirality information applicable to molecular materials with negligible vapor pressure, for example, amino acids. To this end, glutamic acid and 3,4-dihydroxyphenylalanine (DOPA) have been electrosprayed into the source of a chirality spectrometer, where photodetachment is enforced and the PECD is detected. The technique can be expected to be conceptually applicable to all chemical systems with chirality based on molecular properties.
化合物的手性在科学和技术中具有毋庸置疑的重要性。特别是在药理学应用方面，近年来为气相分析物开发的强大技术无法获得大多数感兴趣的分子。在这里，我们证明了电喷雾电离（ESI）与光电子圆二色性（PECD）检测的结合，为具有可忽略蒸气压的分子材料（例如氨基酸）提供了可应用的手性信息。为此，谷氨酸和 3,4-二羟基苯丙氨酸（DOPA）已被电喷雾到手性光谱仪的源中，在那里强制进行光电子离解并检测 PECD。该技术有望在概念上适用于所有基于分子性质的具有手性的化学系统。
