Gonçalves Maria DA Conceição R, Miranda Neto Manoel, Cavalcante Isa G M, Sebadelhe Vittória R R J, Souza Michele F De, Neves Juliana P R, Souza Flavia T L DE, Tavares Renata L, Costa Matheus S, Silva Alexandre S
Programa de Pós-Graduação em Ciências da Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Campus I, Cidade Universitária, 58059-900 João Pessoa, PB, Brazil.
Laboratório de Estudos do Treinamento Físico Aplicado ao Desempenho e a Saúde, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Campus I, Cidade Universitária, 58051-900 João Pessoa, PB, Brazil.
An Acad Bras Cienc. 2020 Mar 16;92(1):e20190227. doi: 10.1590/0001-3765202020190227. eCollection 2020.
Given the scarcity of studies with elderly and the existence of studies investigating the effect of vitamin D supplementation in PEH (post exercise hypotension), this study evaluated the effect of a single megadose of vitamin D on resting blood pressure (RBP) and post-exercise hypotension (PEH) in the elderly. 11 hypertensive elderly women (70.3 ± 1.7 years) received a single megadose of 200.000 IU of cholecalciferol or a placebo, orally, through capsules. On day 7, the subjects performed 30 minutes of aerobic exercise with blood pressure measurement before exercise and every 10 minutes after exercise during 60 minutes, besides cardiac autonomic modulation. RBP did not significantly change. Exercise promoted significant systolic PEH only in one moment post exercise in treated group and in the placebo group promoted significant systolic PEH at four moments. Significant diastolic PEH did not occur in any of the groups. Sympathovagal activity increased at post exercise balance in supplemented subjects at 20 min, 40 min, 50 min and 60 min when compared to rest; this increase was not observed in the placebo. A megadose of vitamin D did not reduce RBP, promoted partial inhibition of systolic PEH and increased sympathovagal balance.
鉴于针对老年人的研究稀缺，且存在关于补充维生素D对运动后低血压（PEH）影响的研究，本研究评估了单次大剂量维生素D对老年人静息血压（RBP）和运动后低血压（PEH）的影响。11名高血压老年女性（70.3±1.7岁）通过胶囊口服接受了单次200,000 IU胆钙化醇大剂量给药或安慰剂。在第7天，受试者进行了30分钟的有氧运动，除了进行心脏自主神经调节外，在运动前以及运动后60分钟内每隔10分钟测量一次血压。静息血压没有显著变化。运动仅在治疗组运动后的一个时刻促进了显著的收缩压运动后低血压，而在安慰剂组运动后的四个时刻促进了显著的收缩压运动后低血压。任何一组均未出现显著的舒张压运动后低血压。与休息时相比，补充维生素D的受试者在运动后20分钟、40分钟、50分钟和60分钟的平衡状态下交感迷走神经活动增加；安慰剂组未观察到这种增加。大剂量维生素D并未降低静息血压，部分抑制了收缩压运动后低血压，并增加了交感迷走神经平衡。
