Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Arq Bras Cardiol. 2024 Apr;121(5):e20230678. doi: 10.36660/abc.20230678.
Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation.
To evaluate the effects of vitamin D3 supplementation on central hemodynamic parameters and autonomic activity in obese/overweight individuals with low vitamin D levels (<30ng/dl).
Adults 40-65 years old with body mass index ≥25<40 kg/m2 were enrolled in this prospective, randomized, double-blind clinical trial (NCT05689632). Central hemodynamics was assessed using the oscillometric method (Mobil-O-Graph®), and heart rate variability using a Polar heart rate monitor (Kubios® software). Patients (n=53) received a placebo in the control group (CO, n=25) or vitamin D3 (VD, n=28) 7000 IU/day, and were evaluated before (W0) and after 8 weeks (W8) with a significance level of 0.05.
The groups were homogeneous regarding age (51±6 vs 52±6 years, p=0.509) and vitamin D levels (22.8±4.9 vs 21.7±4.5ng/ml, p=0.590). At W8, the VD group had significantly higher levels of vitamin D (22.5 vs 35.6ng/ml, p<0.001). Only the VD group showed a significant reduction in systolic blood pressure (SBP; 123±15 vs 119±14mmHg, p=0.019) and alkaline phosphatase (213±55 vs 202±55mg/dl, p=0.012). The CO group showed an increase in augmentation pressure (AP: 9 vs 12 mmHg, p=0.028) and augmentation index (AIx: 26 vs 35%, p=0.020), which was not observed in the VD group (AP: 8 vs 8 mmHg, AIx: 26 vs 25%, p>0.05). VD group showed an increase in the parasympathetic nervous system index (PNSi) (-0.64±0.94 vs -0.16±1.10, p=0.028) and the R-R interval (866±138 vs 924±161 ms, p= 0.026).
In this sample, eight weeks of daily vitamin D supplementation resulted in an improvement in blood pressure levels and autonomic balance.
先前的研究结果并不一致，无法明确维生素 D 补充对心血管的有益作用。
评估维生素 D3 补充对维生素 D 水平较低（<30ng/dl）的肥胖/超重个体中心血管参数和自主活动的影响。
本前瞻性、随机、双盲临床试验（NCT05689632）纳入 40-65 岁、BMI≥25<40kg/m2 的成年人。采用振荡法（Mobil-O-Graph®）评估中心血管动力学，使用 Polar 心率监测仪（Kubios®软件）评估心率变异性。患者（n=53）被随机分为对照组（CO，n=25）或维生素 D3 组（VD，n=28），每天服用 7000IU 维生素 D3。在 8 周（W8）时进行评估，以 0.05 为显著性水平。
两组年龄（51±6 岁 vs 52±6 岁，p=0.509）和维生素 D 水平（22.8±4.9ng/ml vs 21.7±4.5ng/ml，p=0.590）具有同质性。在 W8 时，VD 组的维生素 D 水平显著升高（22.5ng/ml vs 35.6ng/ml，p<0.001）。仅 VD 组的收缩压（SBP；123±15mmHg vs 119±14mmHg，p=0.019）和碱性磷酸酶（213±55mg/dl vs 202±55mg/dl，p=0.012）显著降低。CO 组的增强压（AP；9mmHg vs 12mmHg，p=0.028）和增强指数（AIx；26% vs 35%，p=0.020）增加，而 VD 组未观察到这一变化（AP；8mmHg vs 8mmHg，AIx；26% vs 25%，p>0.05）。VD 组副交感神经指数（PNSi；-0.64±0.94 比 -0.16±1.10，p=0.028）和 R-R 间期（866±138ms vs 924±161ms，p=0.026）增加。
在本样本中，每日补充 8 周维生素 D 可改善血压水平和自主平衡。
