Institute of Organic Chemistry and Biochemistry Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic.
Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 12116, Prague 2, Czech Republic.
Chempluschem. 2020 Mar;85(3):561-575. doi: 10.1002/cplu.202000014. Epub 2020 Mar 18.
Chiroptical spectroscopy exploring the interaction of matter with polarized light provides many tools for molecular structure and interaction studies. Here, some recent discoveries are reviewed, primarily in the field of vibrational optical activity. Technological advances results in the development of more sensitive vibrational circular dichroism (VCD), Raman optical activity (ROA) or circular polarized luminescence (CPL) spectrometers. Significant contributions to the field also come from the light scattering and electronic structure theories, and their implementation in computer systems. Finally, new chiroptical phenomena have been observed, such as enhanced circular dichroism of biopolymers (protein fibrils, nucleic acids), plasmonic and resonance chirality-transfer ROA experiments. Some of them are not yet understood or attributed to instrumental artifacts so far. Nevertheless, these unknown territories also indicate the vast potential of the chiroptical spectroscopy, and their investigation is even more challenging.
手性光谱学探索物质与偏振光的相互作用，为分子结构和相互作用研究提供了许多工具。在这里，主要回顾了振动旋光活性领域的一些最新发现。技术进步导致更灵敏的振动圆二色性（VCD）、拉曼旋光（ROA）或圆偏振发光（CPL）光谱仪的发展。该领域的重要贡献还来自光散射和电子结构理论，以及它们在计算机系统中的实现。最后，观察到了新的手性现象，如生物聚合物（蛋白原纤维、核酸）、等离子体和共振手性转移 ROA 实验的增强圆二色性。其中一些到目前为止还没有得到理解或归因于仪器伪影。然而，这些未知领域也表明了手性光谱学的巨大潜力，对它们的研究更具挑战性。
