Department of Environmental Science and Engineering, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, P. R. China.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Chempluschem. 2020 Mar;85(3):510-518. doi: 10.1002/cplu.202000083.
Photodynamic therapy (PDT), as an emerging clinical approach, has been exploited for the treatment of various diseases including cancer for several years. Excitation light and molecular oxygen are the key parameters that restrict the efficacy of PDT due to the restricted penetration depth of light and the hypoxic microenvironment of tumors, which will lead to ineffective therapeutic response. In recent years, a number of studies were focused on tackling these challenges and showed great potential in improving the efficacy of PDT to some degree. Herein, we summarize the advancements in newly developed PDT strategies based on diverse nanocomposites, especially in the aspects of the types of light source and the ways to supply oxygen. Finally, new challenges and possible opportunities for further research are also discussed.
光动力疗法（PDT）作为一种新兴的临床方法，已经被用于治疗多种疾病，包括癌症，已有数年。由于光的穿透深度有限以及肿瘤的缺氧微环境，激发光和分子氧是限制 PDT 疗效的关键参数，这将导致治疗反应无效。近年来，许多研究集中在解决这些挑战上，并在一定程度上显示出改善 PDT 疗效的巨大潜力。在此，我们总结了基于各种纳米复合材料的新型 PDT 策略的进展，特别是在光源类型和供氧方式方面。最后，还讨论了新的挑战和进一步研究的可能机会。
