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聚乳酸 Cage 复合涂层八钙磷灰石/胶原骨增量

Bone augmentation by octacalcium phosphate and collagen composite coated with poly-lactic acid cage.

机构信息

Bone Regenerative Engineering Laboratory, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

出版信息

Clin Exp Dent Res. 2020 Aug;6(4):391-399. doi: 10.1002/cre2.287. Epub 2020 Mar 18.

DOI:10.1002/cre2.287
PMID:32187863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7453772/
Abstract

OBJECTIVE

Although octacalcium phosphate and collagen composite (OCP/Col) has demonstrated excellent bone regeneration, it has never achieved bone augmentation. The present study investigated whether it could be enabled by OCP/Col disks treated with parathyroid hormone (PTH) and covered with a poly-lactic acid (PLA) cage.

MATERIALS AND METHODS

The prepared OCP/Col disks with three different types of PLA cages (no hole, one large hole, several small holes) were implanted into subperiosteal pockets in rodent calvaria. Histological, and histomorphometric analyses were conducted at 12 weeks after implantation.

RESULTS

Implants with all PLA cage variants achieved sufficient bone augmentation, and analyses showed that new bone was formed from the original bone and along the PLA cage. While the PLA cage variant with no holes sporadically evoked new bone formation even at the central area of the roof of the PLA cage, the PLA cage variants with holes had no new bone in the area of the hole or beneath the periosteum.

CONCLUSIONS

These results suggest that sufficient bone augmentation could be achieved by treating the OCP/Col disks with PTH and covering them with a PLA cage, and periosteum might not have been involved in the bone formation in this experiment.

摘要

目的

尽管八钙磷灰石和胶原复合材料（OCP/Col）已被证明具有优异的骨再生能力，但它从未实现过骨增量。本研究探讨了经甲状旁腺激素（PTH）处理并用聚乳酸（PLA）笼覆盖的 OCP/Col 盘是否可以实现这一目标。

材料和方法

将制备的 OCP/Col 盘用三种不同类型的 PLA 笼（无孔、一大孔、多孔）植入啮齿动物颅骨的骨膜下袋中。在植入后 12 周进行组织学和组织形态计量学分析。

结果

所有 PLA 笼变体的植入物都实现了足够的骨增量，分析表明新骨是从原始骨和 PLA 笼形成的。虽然无孔 PLA 笼变体在 PLA 笼顶的中央区域也偶尔会引发新骨形成，但有孔 PLA 笼变体在孔区域或骨膜下没有新骨形成。

结论

这些结果表明，通过用 PTH 处理 OCP/Col 盘并用 PLA 笼覆盖它们，可以实现足够的骨增量，并且在本实验中，骨膜可能没有参与骨形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/691b9443357b/CRE2-6-391-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/77f3881334d7/CRE2-6-391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/89f9b1dd09b8/CRE2-6-391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/153a09983572/CRE2-6-391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/242d5dd971be/CRE2-6-391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/45154024bced/CRE2-6-391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/f4e32435f86e/CRE2-6-391-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/5309d083c553/CRE2-6-391-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/691b9443357b/CRE2-6-391-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/77f3881334d7/CRE2-6-391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/89f9b1dd09b8/CRE2-6-391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/153a09983572/CRE2-6-391-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/242d5dd971be/CRE2-6-391-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/45154024bced/CRE2-6-391-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/f4e32435f86e/CRE2-6-391-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/5309d083c553/CRE2-6-391-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f20/7453772/691b9443357b/CRE2-6-391-g008.jpg

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