Division of Oral Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):9-17. doi: 10.1016/j.oooo.2011.12.029. Epub 2012 Aug 15.
The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP).
A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation.
Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P < .05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP.
These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.
本研究评估了合成八钙磷酸（OCP）颗粒与猪去端肽胶原（OCP/Col）和β-磷酸三钙（β-TCP）联合使用的骨再生效果。
将 OCP/Col（直径 20mm，厚 2.5mm）或市售烧结多孔β-TCP 盘状植入成年雄性犬的临界尺寸颅骨缺损（直径 20mm）中。植入后 6 个月，通过放射学、结晶学、组织学和组织形态计量学分析缺陷中新生骨的情况。
组织形态计量学显示，OCP/Col 治疗组的新生骨量明显多于β-TCP（P<.05）。植入 OCP/Col 的 X 射线衍射图谱与原始骨相似，与植入的β-TCP 不同。
这些结果表明，与最常用的合成骨替代物β-TCP 相比，OCP/Col 植入犬临界尺寸缺损可增强骨再生效果。
