Lu Q, Yu J X, Lyu C, Shi R, Tian Y
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Mar 6;54(3):289-293. doi: 10.3760/cma.j.issn.0253-9624.2020.03.009.
To understand the levels of Pb, Cd, As, Hg, Mn, and Se in maternal and umbilical cord blood, and to explore the transplacental transfer efficiency (TTE). From September 2010 to December 2013, a total of 773 pregnant women and their newborns (Laizhou Bay Birth Cohort) were recruited from a second grade hospital in the south bank of Laizhou Bay, Bohai, Shandong Province. According to different detection methods, the six measured elements are classified into three groups including the Hg measurement group (595 mother-newborn pairs), the Pb measurement group (534 mother-newborn pairs), and the Cd, As, Mn and Se measurement group (244 mother-newborn pairs). The demographic characteristics of pregnant women and their newborns were obtained by the questionnaire. The concentrations of elements in maternal and umbilical cord blood were detected and the TTE of each element (elemental concentration in cord blood/elemental concentration in maternal blood) was calculated. The correlation of elements between maternal and cord blood was analyzed using Spearman's rank correlation coefficient. The ± of maternal age, gestational week and newborn birth weight of 773 mother-infant pairs were (28.34±4.50) years, (39.47±1.39) weeks and (3 419.47±497.39) g respectively. The median concentrations of Pb, Cd, As, Hg, Mn and As in maternal and cord blood were 31.12 and 30.02, 1.19 and 0.47, 8.05 and 6.03, 0.69 and 1.26, 100.70 and 105.55, 127.25 and 115.00 μg/L, respectively. The TTE of Pb, Cd, As, Hg, Mn, and Se was 0.98, 0.41, 0.73, 1.73, 0.96 and 0.91, respectively. Pb, Cd, Hg, Mn, and Se showed a significant positive correlation between maternal blood and cord blood, with Spearman correlation coefficients of 0.397, 0.298, 0.698, 0.555, and 0.285 (all values<0.001). Each element was commonly detected in maternal blood and cord blood. The TTE of Hg was the highest.
了解母血和脐血中铅、镉、砷、汞、锰和硒的含量，并探讨经胎盘转运效率（TTE）。2010年9月至2013年12月，从山东省渤海莱州湾南岸的一家二级医院招募了773名孕妇及其新生儿（莱州湾出生队列）。根据不同的检测方法，将所测的6种元素分为3组，包括汞检测组（595对母婴）、铅检测组（534对母婴）以及镉、砷、锰和硒检测组（244对母婴）。通过问卷调查获取孕妇及其新生儿的人口统计学特征。检测母血和脐血中元素的浓度，并计算各元素的经胎盘转运效率（脐血中元素浓度/母血中元素浓度）。采用Spearman等级相关系数分析母血与脐血中元素的相关性。773对母婴的母亲年龄、孕周和新生儿出生体重的均值±标准差分别为（28.34±4.50）岁、（39.47±1.39）周和（3419.47±497.39）g。母血和脐血中铅、镉、砷、汞、锰和硒的中位数浓度分别为31.12和30.02、1.19和0.47、8.05和6.03、0.69和1.26、100.70和105.55、127.25和115.00μg/L。铅、镉、砷、汞、锰和硒的经胎盘转运效率分别为0.98、0.41、0.73、1.73、0.96和0.91。铅、镉、汞、锰和硒在母血与脐血之间呈显著正相关，Spearman相关系数分别为0.397、0.298、0.698、0.555和0.285（所有P值<0.001）。各元素在母血和脐血中均普遍检出。汞的经胎盘转运效率最高。
