Department of Gynecology and Obstetrics, Faculty of Medicine, Hitit University, Corum, Turkey.
Department of Medical Pharmacology, Faculty of Medicine, Kirikkale University, Yahsihan, Kirikkale, Turkey.
Biol Trace Elem Res. 2019 Oct;191(2):306-312. doi: 10.1007/s12011-018-1625-2. Epub 2019 Jan 2.
Environmental pollution and exposure of people to heavy metals cause many bad obstetric outcomes. Our aim is to demonstrate the role of cadmium (Cd), lead (Pb), mercury (Hg), and selenium (Se) in preterm labor etiology with a case-control study. In this study, between November 2017 and April 2018, preterm delivery mothers and term delivery mothers were compared in Çorum, Turkey. All deliveries were performed with cesarean sections and there were 30 mothers in the control group and 20 in the study group. The maternal blood, maternal urine, umbilical cord blood, and heavy metal levels in the amnion fluid in both groups were studied. Graphite furnace atomic absorption spectrometry was used to determine the blood concentration of Cd, Pb, Hg, and Se. We found lower levels of selenium in blood and urine of preterm delivery mothers and umbilical cord and amnion fluids of preterm infants (p < 0.01). We found a statistically significant positive correlation at selenium levels between mother's blood and umbilical cord blood (r (50) = 0.896, p < 0.001) and between maternal urine and amniotic fluid (r (50) = 0.841, p < 0.001). We have not found a similar correlation between mother and fetus of other metals (p > 0.05). We found that selenium levels were lower in mothers who were preterm birth in the light of the data in our study. We could not determine the positive or negative correlation of Cd, Pb, and Hg levels in blood, urine, and amniotic fluid samples with preterm birth.
环境污染和人们接触重金属会导致许多不良的产科结局。我们的目的是通过病例对照研究来证明镉（Cd）、铅（Pb）、汞（Hg）和硒（Se）在早产病因中的作用。在这项研究中，2017 年 11 月至 2018 年 4 月期间，我们在土耳其科鲁姆比较了早产母亲和足月分娩母亲。所有分娩均采用剖宫产，对照组有 30 名母亲，研究组有 20 名母亲。研究了两组产妇血液、产妇尿液、脐带血和羊膜液中的重金属水平。采用石墨炉原子吸收光谱法测定血液中 Cd、Pb、Hg 和 Se 的浓度。我们发现早产母亲的血液和尿液以及早产儿的脐带和羊膜液中的硒水平较低（p<0.01）。我们发现母亲血液和脐带血（r（50）=0.896，p<0.001）以及母亲尿液和羊水（r（50）=0.841，p<0.001）之间的硒水平存在统计学上显著的正相关。我们没有发现其他金属（p>0.05）在母亲和胎儿之间存在类似的相关性。根据我们的研究数据，我们发现硒水平较低的母亲更容易早产。我们无法确定血液、尿液和羊膜液样本中 Cd、Pb 和 Hg 水平与早产之间的正相关或负相关。
