Lee Kyung-Ann, Lee Sang-Heon, Kim Hae-Rim
Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul hospital, Seoul 04401, Korea.
Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Research institute of medical science, Konkuk University School of Medicine, Seoul 05030, Korea.
J Clin Med. 2020 Mar 16;9(3):803. doi: 10.3390/jcm9030803.
We aimed to evaluate the changes over time in salivary gland (SG) abnormalities by ultrasound (US) in patients with primary Sjögren's syndrome (pSS). Patients with pSS ( = 70) and idiopathic sicca syndrome ( = 18) underwent baseline salivary gland ultrasound (SGUS) scans, and follow-up scans two years later. The semi-quantitative SGUS score (0-48) and intraglandular power Doppler signal (PDS) were assessed. We found that in the pSS group, the SGUS scores for total SGs and bilateral parotid glands significantly increased after the median 23.4-months follow-up. SGUS scores either worsened, improved, or were stable in 18.6%, 2.9%, and 78.6% of patients with pSS, respectively. The median changes from baseline in SGUS scores for total and parotid glands were +1.0 and +0.5, respectively. None of the SGUS scores changed significantly in the controls. The variables of homogeneity and hypoechoic showed a statistically significant progression of SGUS scores. In pSS patients, the baseline and follow-up PDS scores were significantly higher in the "worsening" group than in the "no change/improvement" group. Overall, the structural abnormalities in major SGs assessed using SGUS remained stable in patients with pSS. At the 2-year follow-up, SGUS scores worsened in 18.6% of patients with pSS. Intra-glandular hypervascularity was associated with the worsening of SG abnormalities.
我们旨在评估原发性干燥综合征（pSS）患者唾液腺（SG）异常通过超声（US）随时间的变化。pSS患者（n = 70）和特发性干燥综合征患者（n = 18）接受了基线唾液腺超声（SGUS）扫描，并在两年后进行了随访扫描。评估了半定量SGUS评分（0 - 48）和腺体内功率多普勒信号（PDS）。我们发现，在pSS组中，中位随访23.4个月后，总唾液腺和双侧腮腺的SGUS评分显著增加。pSS患者中，SGUS评分恶化、改善或稳定的比例分别为18.6%、2.9%和78.6%。总唾液腺和腮腺的SGUS评分相对于基线的中位变化分别为 +1.0和 +0.5。对照组中SGUS评分均无显著变化。均匀性和低回声变量显示SGUS评分有统计学意义的进展。在pSS患者中，“恶化”组的基线和随访PDS评分显著高于“无变化/改善”组。总体而言，pSS患者中使用SGUS评估的主要唾液腺结构异常保持稳定。在2年随访时，18.6%的pSS患者SGUS评分恶化。腺体内血管增多与唾液腺异常恶化相关。
