抗着丝点抗体阳性原发性干燥综合征中大唾液腺的超声特征。
Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.
机构信息
Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
PLoS One. 2021 Nov 3;16(11):e0259519. doi: 10.1371/journal.pone.0259519. eCollection 2021.
PURPOSE
To investigate salivary gland ultrasonography (SGUS) findings in primary Sjögren's syndrome (pSS) patients positive for the anti-centromere antibody (ACA) and compare these with those in ACA-negative pSS patients.
METHODS
We analyzed demographic, clinical, laboratory, and SGUS data of pSS patients who fulfilled the 2002 American-European Consensus Group classification criteria for pSS. SGUS findings of four major salivary glands (bilateral parotid and submandibular glands) were scored in five categories and compared between ACA-positive and ACA-negative pSS patients. Linear regression analysis was performed to elucidate the factors associated with SGUS score.
RESULTS
In total, 121 pSS patients were enrolled (19, ACA-positive). The ACA-positive patients were older (67.0 vs 58.0 years, P = 0.028), whereas anti-Ro/SSA and anti-La/SSB positivity was more prevalent in the ACA-negative group (89.2% vs 21.1%, P < 0.001, and 47.1% vs 10.5%, P = 0.007, respectively). The total SGUS and hypoechoic area scores were lower in ACA-positive patients (16.0 vs 23.0, P = 0.027, and 4.0 vs 7.0, P = 0.004, respectively). In univariate regression analysis, being positive for unstimulated salivary flow rate (USFR < 1.5 ml/15 min), anti-Ro/SSA, and rheumatoid factor were positively associated whereas ACA positivity was negatively associated with the SGUS score. In multivariate regression analysis, being positive for USFR, anti-Ro/SSA, and rheumatoid factor showed significant association with the SGUS score.
CONCLUSIONS
ACA-positive pSS patients showed a lower SGUS score than ACA-negative patients, which was especially prominent in the hypoechoic area component.
目的
研究抗着丝点抗体（ACA）阳性原发性干燥综合征（pSS）患者的唾液腺超声（SGUS）表现，并与 ACA 阴性 pSS 患者进行比较。
方法
我们分析了符合 2002 年美国-欧洲共识组 pSS 分类标准的 pSS 患者的人口统计学、临床、实验室和 SGUS 数据。对四大唾液腺（双侧腮腺和颌下腺）的 SGUS 表现进行了五类评分，并比较了 ACA 阳性和 ACA 阴性 pSS 患者之间的评分。进行线性回归分析以阐明与 SGUS 评分相关的因素。
结果
共纳入 121 例 pSS 患者（19 例为 ACA 阳性）。ACA 阳性患者年龄较大（67.0 岁 vs 58.0 岁，P=0.028），而 ACA 阴性组抗 Ro/SSA 和抗 La/SSB 阳性率更高（89.2% vs 21.1%，P<0.001；47.1% vs 10.5%，P=0.007）。与 ACA 阴性患者相比，ACA 阳性患者的总 SGUS 和低回声面积评分较低（16.0 分 vs 23.0 分，P=0.027；4.0 分 vs 7.0 分，P=0.004）。在单变量回归分析中，未刺激唾液流率（USFR<1.5 ml/15 min）、抗 Ro/SSA 和类风湿因子阳性与 SGUS 评分呈正相关，而 ACA 阳性与 SGUS 评分呈负相关。在多变量回归分析中，USFR、抗 Ro/SSA 和类风湿因子阳性与 SGUS 评分显著相关。
结论
与 ACA 阴性患者相比，ACA 阳性的 pSS 患者的 SGUS 评分较低，尤其在低回声区更为明显。
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