Fayyaz Anum, Kurien Biji T, Scofield R Hal
Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA.
Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA.
Rheum Dis Clin North Am. 2016 Aug;42(3):419-34. doi: 10.1016/j.rdc.2016.03.002. Epub 2016 Jun 21.
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.
我们收集了有关干燥综合征中抗体的信息，重点关注与抗Ro/SSA和抗La/SSB抗体相关的临床表现以及关于新型抗体的研究。我们回顾了以前以及最近以“干燥综合征”与“抗体”和“先天性心脏传导阻滞（CHB）”相结合为主题的研究。几乎一半生下患有CHB孩子的无症状母亲最终会患上干燥综合征。我们讨论了有关在疾病临床表现之前存在抗体的研究。未来需要开展研究以确定与这些抗体相关的致病机制以及与新自身抗体相关的具体临床表现。
