Research Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, Russia.
Federal State Budgetary Institution "Federal Center for Cerebrovascular Pathology and Stroke", 1, stroenie 10, Ostrovityanova, 117342 Moscow, Russia.
Int J Mol Sci. 2020 Mar 16;21(6):2036. doi: 10.3390/ijms21062036.
Increased salt intake in food probably affects the progression of cerebral small vessel disease (CSVD), which justifies the study of disturbances in sodium homeostasis associated with the development of CSVD. We aimed to clarify the role of salt sensitivity and osmotic fragility in the development of CSVD. Erythrocyte salt sensitivity was measured using the modified salt blood test, and osmotic fragility was measured using the classic osmotic fragility test in 73 patients with CSVD (48 women; 60.1 ± 6.5 years) and 19 healthy volunteers (14 women; 56.9 ± 6.4 years). Salt sensitivity and osmotic fragility exhibited a predictive value in relation to CSVD. These parameters were associated with an increase in white matter hyperintensities ( = 0.019 and 0.004, respectively). Their simultaneous use increased their predictive ability for CSVD ( < 0.000001; AUC (95% CI), 0.824 (0.724-0.923)). The possibility of predicting CSVD using erythrocyte salt sensitivity and osmotic fragility indicates the value of the individual glycocalyx buffer capacity in relation to sodium and the activity of sodium channels in the development of CSVD. Increased salt sensitivity and osmotic fragility seem to be risk factors for CSVD.
食物中盐摄入量的增加可能会影响脑小血管病（CSVD）的进展，这就需要研究与 CSVD 发展相关的钠平衡紊乱。我们旨在阐明红细胞盐敏感性和渗透脆性在 CSVD 发展中的作用。在 73 例 CSVD 患者（48 名女性；60.1 ± 6.5 岁）和 19 名健康志愿者（14 名女性；56.9 ± 6.4 岁）中，使用改良盐血试验测量红细胞盐敏感性，使用经典渗透脆性试验测量渗透脆性。盐敏感性和渗透脆性对 CSVD 具有预测价值。这些参数与脑白质高信号（分别为 = 0.019 和 0.004）相关。同时使用这些参数增加了它们对 CSVD 的预测能力（<0.000001；AUC（95%CI），0.824（0.724-0.923））。使用红细胞盐敏感性和渗透脆性预测 CSVD 的可能性表明，个体糖萼缓冲能力与钠和钠通道活性在 CSVD 发展中的重要性。盐敏感性和渗透脆性增加似乎是 CSVD 的危险因素。
