中国早发性雄激素性脱发：一项大型门诊队列的描述性研究

Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort.

作者信息

Ding Qi, Xu Yu-Xuan, Sun Wei-Ling, Liu Jing-Jing, Deng Yu-Yu, Wu Qiao-Fang, Cao Chun-Yu, Zhou Lan-Bo, Lu Yan, Fan Wei-Xin

机构信息

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

出版信息

J Int Med Res. 2020 Mar;48(3):300060519897190. doi: 10.1177/0300060519897190.

OBJECTIVE

To describe the clinical features of early-onset androgenetic alopecia (AGA) in a large cohort of Chinese patients.

METHODS

This descriptive study recruited consecutive patients seeking medical treatment for AGA between 1 January 2013 and 30 November 2018. Patients were included in the study if they reported being ≤35 years old at AGA onset and if their pattern of hair loss was documented with photographs. The age of onset, sex, body mass index (BMI), BAsic and SPecific classification of hair loss and family history of alopecia were collected in an electronic database.

RESULTS

A total of 3897 patients with early-onset AGA were recruited to the study. The majority of patients (70.6%; 2751 of 3897) were 21–30 years old and male (72.7%; 2834 of 3897). No association was found between high BMI (≥25 kg/m) and early-onset AGA. There were significantly more overweight male AGA patients than overweight female patients (86.8% [632 of 728] versus 13.2% [96 of 728], respectively). The overall prevalence of familial AGA was 72.8% (2837 of 3897) and the condition was inherited more often from the father (52.8%; 1498 of 2837) than from the mother (24.3%; 688 of 2837).

CONCLUSIONS

Early-onset AGA primarily affects male patients between 21–30 years of age. Males with early-onset AGA are likely to have inherited AGA from their fathers.

目的

描述一大群中国早发性雄激素性脱发（AGA）患者的临床特征。

方法

这项描述性研究纳入了2013年1月1日至2018年11月30日期间因AGA前来就医的连续患者。如果患者报告AGA发病时年龄≤35岁且其脱发模式有照片记录，则纳入本研究。在电子数据库中收集发病年龄、性别、体重指数（BMI）、脱发的基本和特定分类以及脱发家族史。

结果

本研究共纳入3897例早发性AGA患者。大多数患者（70.6%；3897例中的2751例）年龄在21 - 30岁之间且为男性（72.7%；3897例中的2834例）。未发现高BMI（≥25kg/m²）与早发性AGA之间存在关联。超重的男性AGA患者明显多于超重的女性患者（分别为86.8%[728例中的632例]和13.2%[728例中的96例]）。家族性AGA的总体患病率为72.8%（3897例中的2837例），且该疾病从父亲遗传的情况（52.8%；2837例中的1498例）比从母亲遗传的情况（24.3%；2837例中的688例）更常见。