细胞外囊泡在卵母细胞成熟和早期胚胎发育过程中的作用。
Role of extracellular vesicles during oocyte maturation and early embryo development.
作者信息
de Ávila A C F C M, da Silveira J C
机构信息
Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte 225, 13635-900 Pirassununga, São Paulo, Brazil.
Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte 225, 13635-900 Pirassununga, São Paulo, Brazil; and Corresponding author. Email:
出版信息
Reprod Fertil Dev. 2019 Jan;32(2):56-64. doi: 10.1071/RD19389.
The follicle is a dynamic microenvironment in the ovary where the oocyte develops. Intercellular communication between somatic cells and the oocyte inside the follicle is essential to generate a competent gamete. Extracellular vesicles are nanoparticles secreted by cells that mediate cell-to-cell communication in the follicle microenvironment and can be obtained from the follicular fluid. These extracellular vesicles have been studied as biomarkers and supplementation tools to mimic physiological conditions during assisted reproductive techniques because they are vehicles of bioactive molecules. Therefore, this paper reviews the importance of changes in the ovarian follicle and the effects of extracellular vesicles from follicular fluid during oocyte maturation and early embryo development. Finally, we propose that is important to consider the source of the extracellular vesicles to improve diagnostic methods and to increase invitro embryo production.
卵泡是卵巢中卵母细胞发育的动态微环境。卵泡内体细胞与卵母细胞之间的细胞间通讯对于产生有能力的配子至关重要。细胞外囊泡是细胞分泌的纳米颗粒，介导卵泡微环境中的细胞间通讯，可从卵泡液中获得。这些细胞外囊泡已作为生物标志物和补充工具进行研究，以模拟辅助生殖技术期间的生理条件，因为它们是生物活性分子的载体。因此，本文综述了卵巢卵泡变化的重要性以及卵泡液来源的细胞外囊泡在卵母细胞成熟和早期胚胎发育过程中的作用。最后，我们提出，考虑细胞外囊泡的来源对于改进诊断方法和提高体外胚胎产量很重要。
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