PERK-STING Signaling Drives Neuroinflammation in Traumatic Brain Injury.
作者信息
Chin Alfred C
机构信息
Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York 10065
出版信息
J Neurosci. 2020 Mar 18;40(12):2384-2386. doi: 10.1523/JNEUROSCI.2881-19.2020.
Abstract
摘要
相似文献
1
PERK-STING Signaling Drives Neuroinflammation in Traumatic Brain Injury.PERK-STING信号通路驱动创伤性脑损伤中的神经炎症。
J Neurosci. 2020 Mar 18;40(12):2384-2386. doi: 10.1523/JNEUROSCI.2881-19.2020.
2
Aberrant ER Stress Induced Neuronal-IFNβ Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI.内质网应激诱导的神经元-IFNβ异常激活导致创伤性脑损伤后白质损伤，其原因是小胶质细胞激活和 T 细胞浸润。
J Neurosci. 2020 Jan 8;40(2):424-446. doi: 10.1523/JNEUROSCI.0718-19.2019. Epub 2019 Nov 6.
3
Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury.创伤性脑损伤后白质病理与可塑性中的髓磷脂和少突胶质细胞谱系细胞
Neuropharmacology. 2016 Nov;110(Pt B):654-659. doi: 10.1016/j.neuropharm.2015.04.029. Epub 2015 May 9.
4
Progression of histopathological and behavioral abnormalities following mild traumatic brain injury in the male ferret.雄性雪貂轻度创伤性脑损伤后组织病理学和行为异常的进展。
J Neurosci Res. 2018 Apr;96(4):556-572. doi: 10.1002/jnr.24218. Epub 2018 Jan 23.
5
Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury.Sarm1 缺失可减少实验性颅脑损伤后的轴突损伤、脱髓鞘和白质萎缩。
Exp Neurol. 2019 Nov;321:113040. doi: 10.1016/j.expneurol.2019.113040. Epub 2019 Aug 21.
6
White Matter and Cognition in Traumatic Brain Injury.脑创伤中的白质与认知。
J Alzheimers Dis. 2018;65(2):345-362. doi: 10.3233/JAD-180287.
7
Pain-related white matter tract abnormalities in mild traumatic brain injury patients with persistent headache.轻度创伤性脑损伤患者持续性头痛相关的痛觉相关白质束异常。
Mol Pain. 2018 Jan-Dec;14:1744806918810297. doi: 10.1177/1744806918810297. Epub 2018 Oct 16.
8
Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts.小鼠弥漫性创伤性脑损伤会诱导损伤白质束中少突胶质细胞祖细胞的短暂增殖。
Restor Neurol Neurosci. 2017;35(2):251-263. doi: 10.3233/RNN-160675.
9
Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery.实验性创伤性脑损伤确定了白质病理生理学的明显早期和晚期阶段轴突传导缺陷，并揭示了干预后的恢复。
J Neurosci. 2018 Oct 10;38(41):8723-8736. doi: 10.1523/JNEUROSCI.0819-18.2018. Epub 2018 Aug 24.
10
Deep white matter hyperintensities affect verbal memory independent of PTSD symptoms in veterans with mild traumatic brain injury.深部白质高信号独立于创伤后应激障碍症状影响轻度创伤性脑损伤退伍军人的言语记忆。
Brain Inj. 2016;30(7):864-71. doi: 10.3109/02699052.2016.1144894. Epub 2016 Apr 8.
引用本文的文献
1
The cGAS-STING/PERK-eIF2α: Individual or Potentially Collaborative Signaling Transduction in Cardiovascular Diseases.环鸟苷酸合成酶-干扰素基因刺激蛋白/蛋白激酶R样内质网激酶-真核翻译起始因子2α：心血管疾病中的独立或潜在协同信号转导
Int J Biol Sci. 2024 Oct 28;20(15):5868-5887. doi: 10.7150/ijbs.101247. eCollection 2024.
2
Nogo-A exacerbates sepsis-associated encephalopathy by modulating microglial SHP-2/NLRP3 balance and inducing ROS and M1 polarization.Nogo-A通过调节小胶质细胞中SHP-2/NLRP3平衡、诱导活性氧生成和M1极化，加重脓毒症相关性脑病。
Biomol Biomed. 2024 Dec 11;25(1):210-225. doi: 10.17305/bb.2024.10822.
3
Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury.内质网应激与未折叠蛋白反应：创伤性脑损伤进展中的新兴调节因子。
Cell Death Dis. 2024 Feb 20;15(2):156. doi: 10.1038/s41419-024-06515-x.
4
STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases.人类神经退行性疾病中由STING引发的中枢神经系统炎症
Biomedicines. 2023 May 5;11(5):1375. doi: 10.3390/biomedicines11051375.
5
Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway. treadmill 运动中等强度通过抑制 STING 通路拯救 TBI 诱导的铁死亡、神经退行性变和认知障碍。
Mol Neurobiol. 2023 Sep;60(9):4872-4896. doi: 10.1007/s12035-023-03379-8. Epub 2023 May 16.
6
PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis-associated encephalopathy.PERK-STING-RIPK3 通路通过诱导脓毒症相关性脑病中的神经元坏死性凋亡促进认知障碍。
CNS Neurosci Ther. 2023 Apr;29(4):1178-1191. doi: 10.1111/cns.14095. Epub 2023 Jan 24.
7
Intranasal Administration of Agomir-let-7i Improves Cognitive Function in Mice with Traumatic Brain Injury.经鼻给予 Agomir-let-7i 可改善创伤性脑损伤小鼠的认知功能。
Cells. 2022 Apr 15;11(8):1348. doi: 10.3390/cells11081348.
8
cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders.中枢神经系统疾病中干扰素基因信号通路的环鸟苷酸-腺苷酸合成酶刺激因子
Aging Dis. 2021 Oct 1;12(7):1658-1674. doi: 10.14336/AD.2021.0304. eCollection 2021 Oct.
9
Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation.解析线粒体动态与神经炎症之间的联系。
Front Immunol. 2021 Mar 16;12:624919. doi: 10.3389/fimmu.2021.624919. eCollection 2021.
本文引用的文献
1
Interferon-β Plays a Detrimental Role in Experimental Traumatic Brain Injury by Enhancing Neuroinflammation That Drives Chronic Neurodegeneration.干扰素-β 通过增强神经炎症促进慢性神经退行性变，在实验性创伤性脑损伤中起有害作用。
J Neurosci. 2020 Mar 11;40(11):2357-2370. doi: 10.1523/JNEUROSCI.2516-19.2020. Epub 2020 Feb 6.
2
Aberrant ER Stress Induced Neuronal-IFNβ Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI.内质网应激诱导的神经元-IFNβ异常激活导致创伤性脑损伤后白质损伤，其原因是小胶质细胞激活和 T 细胞浸润。
J Neurosci. 2020 Jan 8;40(2):424-446. doi: 10.1523/JNEUROSCI.0718-19.2019. Epub 2019 Nov 6.
3
DNA sensing by the cGAS-STING pathway in health and disease.cGAS-STING 通路在健康和疾病中的 DNA 感应。
Nat Rev Genet. 2019 Nov;20(11):657-674. doi: 10.1038/s41576-019-0151-1. Epub 2019 Jul 29.
4
Neuroinflammation in frontotemporal dementia.额颞叶痴呆的神经炎症。
Nat Rev Neurol. 2019 Sep;15(9):540-555. doi: 10.1038/s41582-019-0231-z. Epub 2019 Jul 19.
5
Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy.STING 通路的药理学调节在癌症免疫治疗中的作用。
Trends Mol Med. 2019 May;25(5):412-427. doi: 10.1016/j.molmed.2019.02.007. Epub 2019 Mar 15.
6
Drug developers switch gears to inhibit STING.药物研发人员转而致力于抑制干扰素基因刺激蛋白（STING）。
Nat Biotechnol. 2019 Mar;37(3):199-201. doi: 10.1038/s41587-019-0060-z.
7
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.mTORC1 对 STING 和 TCR 信号的相互调节对 T 细胞的激活和功能至关重要。
Life Sci Alliance. 2019 Jan 25;2(1). doi: 10.26508/lsa.201800282. Print 2019 Feb.
8
A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis.炎燃景观：神经炎症塑造脑转移。
Cancer Res. 2019 Feb 1;79(3):423-436. doi: 10.1158/0008-5472.CAN-18-1805. Epub 2019 Jan 24.
9
Neuroinflammation and the cGAS-STING pathway.神经炎症与 cGAS-STING 通路。
J Neurophysiol. 2019 Apr 1;121(4):1087-1091. doi: 10.1152/jn.00848.2018. Epub 2019 Jan 23.
10
STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury.STING 介导的 I 型干扰素有助于创伤性脑损伤后的神经炎症过程和不良影响。
J Neuroinflammation. 2018 Nov 21;15(1):323. doi: 10.1186/s12974-018-1354-7.
Zotero 插件