Université de Paris, Epidemiology and Statistics research Center/CRESS, INSERM, INRA, F-75004, Paris, France.
Department of Obstetrics and Gynecology, Robert Debré Hospital, APHP, Paris, France.
Sci Rep. 2020 Mar 18;10(1):4944. doi: 10.1038/s41598-020-61720-w.
Planned vaginal delivery in twin pregnancies has three potential outcomes: vaginal or cesarean delivery of both twins, or cesarean for the second twin. Our objective was to assess the association between delivery mode and severe acute maternal morbidity (SAMM) in women with twin pregnancies and planned vaginal deliveries. We limited this planned secondary analysis of the JUMODA cohort, a national prospective population-based study of twin deliveries, to women with planned vaginal delivery at or after 24 weeks of gestation who gave birth to two live fetuses at hospital. The association between delivery mode and SAMM was estimated from multivariate Poisson regression models. Of 5,055 women with planned vaginal delivery, 4,007 (79.3%) delivered both twins vaginally, 134 (2.6%) had cesarean for the second twin and 914 (18.1%) cesarean for both twins. Compared to vaginal delivery of both twins, the risk of SAMM was significantly higher after cesarean for the second twin (9.0% versus 4.5%; aRR 2.22, 95% CI 1.27-3.88) and for both twins (9.4% versus 4.5%, aRR 1.56, 95% CI 1.16-2.10). In twin pregnancies with planned vaginal delivery, cesarean deliveries for the second twin and for both twins are associated with higher risks of SAMM than vaginal delivery.
阴道分娩或剖宫产分娩两个胎儿,或第二个胎儿行剖宫产。我们的目的是评估在计划阴道分娩的双胎妊娠女性中,分娩方式与严重急性母体并发症(SAMM)之间的关联。我们对 JUMODA 队列(一项全国性的前瞻性基于人群的双胎分娩研究)进行了计划二次分析,该队列仅限于在 24 周或以上时计划阴道分娩且在医院分娩两个活胎的女性。通过多变量泊松回归模型来估计分娩方式与 SAMM 之间的关联。在 5055 名计划阴道分娩的女性中,4007 名(79.3%)阴道分娩两个胎儿,134 名(2.6%)第二个胎儿行剖宫产,914 名(18.1%)两个胎儿均行剖宫产。与阴道分娩两个胎儿相比,第二个胎儿行剖宫产(9.0%比 4.5%;ARR 2.22,95%CI 1.27-3.88)和两个胎儿均行剖宫产(9.4%比 4.5%;ARR 1.56,95%CI 1.16-2.10)的 SAMM 风险显著更高。在计划阴道分娩的双胎妊娠中,第二个胎儿和两个胎儿的剖宫产分娩与 SAMM 风险增加相关。