Instituto Universitario Mixto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València, Consejo Superior de Investigaciones Científicas, Avda de los Naranjos, s/n, 46022, Valencia, Spain.
Chemistry. 2020 Jun 5;26(32):7205-7211. doi: 10.1002/chem.202000123. Epub 2020 Apr 28.
Photolabile protecting groups (PPGs) have been exploited in a wide range of chemical and biological applications, due to their ability to provide spatial and temporal control over light-triggered activation. In this work, we explore the concept of a new photocage compound based on the commercial UVA/UVB filter oxybenzone (OB; 2-hydroxy-4-methoxybenzophenone) for photoprotection and controlled release of carbonyl groups. The point here is that oxybenzone not only acts as a mere PPG, but also provides, once released, UV photoprotection to the carbonyl derivative. This design points to a possible therapeutic approach to reduce the severe photoadverse effects of drugs containing a carbonyl chromophore.
光不稳定保护基团（PPGs）由于能够提供对光触发激活的空间和时间控制，因此在广泛的化学和生物应用中得到了利用。在这项工作中，我们探索了一种基于商业 UVA/UVB 过滤器二苯甲酮-4（OB；2-羟基-4-甲氧基二苯甲酮）的新型光笼化合物的概念，用于羰基基团的光保护和控制释放。这里的关键是，二苯甲酮-4 不仅充当单纯的 PPG，而且一旦释放，还为羰基衍生物提供紫外线防护。这种设计可能为减少含有羰基生色团的药物的严重光不良反应提供一种治疗方法。
