Thientunyakit Tanyaluck, Thongpraparn Thonnapong, Siriprapa Tossaporn, Gelovani Juri G
Department of Radiology, Division of Nuclear Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
NANOTEC-Mahidol University Center of Excellence in Nanotechnology for Cancer Diagnosis and Treatment, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
World J Nucl Med. 2019 Jul 23;19(1):72-77. doi: 10.4103/wjnm.WJNM_91_18. eCollection 2020 Jan-Mar.
We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [F]-2'-fluoro-2'-deoxy-D-glucose ([F]-FDG) and [F]-fluorocholine ([F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [F]-FDG and [F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses. As compared to CT alone, PET/CT with [F]-FDG and [F]-FCH PET/CT revealed more hypermetabolic metastatic lesions in the body, but not in the brain. The standard uptake value of [F]-FDG was generally higher than [F]-FCH in all detectable tumor lesions. In conclusion, both [F]-FDG and [F]-FCH PET/CT can be used for diagnosis and staging for GTN, based on their sensitivity for small extracerebral metastatic lesions. Additional studies are warranted to determine whether the PET/CT imaging with [F]-FDG and [F]-FCH can serve as a biomarker of GTN aggressiveness, for prediction of treatment response.
我们报告了使用[F]-2'-氟-2'-脱氧-D-葡萄糖（[F]-FDG）和[F]-氟胆碱（[F]-FCH）进行双正电子发射断层扫描/计算机断层扫描（PET/CT）成像在妊娠滋养细胞肿瘤（GTN）患者中用于这种罕见的妊娠相关疾病的初步诊断和分期的疗效。连续两天对三名GTN患者进行了[F]-FDG和[F]-FCH全身PET/CT检查。通过视觉和定量分析对每个可检测到的病变进行了特征描述。与单独的CT相比，[F]-FDG和[F]-FCH PET/CT显示身体中有更多的高代谢转移灶，但脑部没有。在所有可检测到的肿瘤病变中，[F]-FDG的标准摄取值通常高于[F]-FCH。总之，基于[F]-FDG和[F]-FCH PET/CT对脑外小转移灶的敏感性，它们均可用于GTN的诊断和分期。有必要进行进一步的研究，以确定[F]-FDG和[F]-FCH PET/CT成像是否可作为GTN侵袭性的生物标志物，用于预测治疗反应。
