Bandy L C, Clarke-Pearson D L, Hammond C B
Obstet Gynecol. 1984 Sep;64(3):395-9.
The effect of maternal age on the incidence and significance of hydatidiform mole in 2202 patients studied at the Southeastern Regional Trophoblastic Disease Center during 1978 to 1982 is analyzed. Results are compared with a contemporary control group that comprised all types of pregnancy events. A significant increase (P less than .001) in the incidence of hydatidiform mole was seen in women 15 years of age or less and 40 years of age or more. A significant decrease (P less than .001) in the incidence of hydatidiform mole was seen in women in the 20 to 29-year age group. The greatest relative risk of hydatidiform mole occurred in women 50 years of age and older (relative risk = 519). The malignant sequelae rate from hydatidiform mole was 21.7% for the entire group. The relative risk of malignant gestational trophoblastic disease was lowest among patients 15 years of age and less (13.9%) and highest in patients 50 years of age and more (37.5%), but the differences were not significant (P greater than .05). The findings of the present study are compared with the previous literature and management recommendations are made.
分析了1978年至1982年期间在东南部地区滋养细胞疾病中心研究的2202例患者中，母亲年龄对葡萄胎发生率及意义的影响。将结果与一个包含所有类型妊娠事件的当代对照组进行比较。15岁及以下和40岁及以上女性的葡萄胎发生率显著增加（P＜0.001）。20至29岁年龄组女性的葡萄胎发生率显著降低（P＜0.001）。50岁及以上女性发生葡萄胎的相对风险最高（相对风险=519）。整个组葡萄胎的恶性后遗症发生率为21.7%。15岁及以下患者发生恶性妊娠滋养细胞疾病的相对风险最低（13.9%），50岁及以上患者最高（37.5%），但差异无统计学意义（P＞0.05）。将本研究结果与以往文献进行比较并提出管理建议。
