Kim Sang Hoon, Kim Ji Hyeong, Keum Bora, Jeon Han Jo, Jang Se Hyun, Choi Seong Ji, Kim Seung Han, Lee Jae Min, Choi Hyuk Soon, Kim Eun Sun, Jeen Yoon Tae, Lee Hong Sik, Chun Hoon Jai, Kim Chang Duck
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Anam-dong, Seongbuk-gu, Seoul 20841, Republic of Korea.
Gastroenterol Res Pract. 2020 Mar 3;2020:9548171. doi: 10.1155/2020/9548171. eCollection 2020.
Patient compliance during bowel preparation is important for successful colonoscopy. Bowel preparation with polyethylene glycol (PEG), the most commonly used solution for cleansing, involves the unpleasant ingestion of a large amount of liquid. Sodium picosulfate magnesium citrate (SP-MC) solution is an alternative option with better palatability than PEG. Therefore, in this study, we compared the efficacy and patient tolerability among the following three bowel preparation protocols: 2 L PEG-ascorbic acid (ASc), 1 L PEG-ASc plus bisacodyl, and SP-MC 340 mL plus bisacodyl. We conducted a randomized prospective endoscopist-blinded study between August 2018 and January 2019. A total of 311 patients were randomly classified into three groups according to the above-described bowel preparation protocols. To evaluate the efficacy of bowel cleansing, we used the Boston Bowel Preparation Scale. The degree of symptoms and the patients' satisfaction with each bowel preparation method were investigated using a questionnaire completed before sedation for colonoscopy. The baseline characteristics were similar among the three groups. There was no significant difference in the bowel preparation quality among the three groups. However, the incidence of symptoms, such as abdominal fullness and pain, was significantly lower ( = 0.006 and 0.027, respectively) while the patients' satisfaction rate was significantly higher ( = 0.012) in the SP-MC plus bisacodyl group than in the two PEG groups. In this study, the efficacy of the SP-MC plus bisacodyl solution was similar to that of the PEG solutions. However, patient tolerability and satisfaction were better in the SP-MC plus bisacodyl group than in the other groups. In conclusion, the use of SP-MC plus bisacodyl bowel preparation solution might be a better method for providing good intestinal cleansing and improving patient compliance.
肠道准备过程中患者的依从性对于结肠镜检查的成功至关重要。聚乙二醇（PEG）是最常用的清洁溶液，用其进行肠道准备需要大量饮用味道不佳的液体。匹可硫酸钠枸橼酸镁（SP-MC）溶液是一种替代选择，其适口性优于PEG。因此，在本研究中，我们比较了以下三种肠道准备方案的疗效和患者耐受性：2L PEG-抗坏血酸（ASc）、1L PEG-ASc加比沙可啶、340mL SP-MC加比沙可啶。我们在2018年8月至2019年1月期间进行了一项随机前瞻性内镜医师盲法研究。根据上述肠道准备方案，共311例患者被随机分为三组。为评估肠道清洁效果，我们使用了波士顿肠道准备量表。在结肠镜检查镇静前，通过问卷调查来调查症状程度和患者对每种肠道准备方法的满意度。三组的基线特征相似。三组之间的肠道准备质量无显著差异。然而，与两个PEG组相比，SP-MC加比沙可啶组腹胀和疼痛等症状的发生率显著更低（分别为P = 0.006和0.027），而患者满意度显著更高（P = 0.012）。在本研究中，SP-MC加比沙可啶溶液的疗效与PEG溶液相似。然而，SP-MC加比沙可啶组的患者耐受性和满意度优于其他组。总之，使用SP-MC加比沙可啶肠道准备溶液可能是实现良好肠道清洁和提高患者依从性的更好方法。
