Cathelineau L, Pages C, Aubier F, Guimbaud P, Narcy P
Centre Thérapeutique Pédiatrique, Hôpital Bretonneau, Paris.
Arch Fr Pediatr. 1988 Jun-Jul;45(6):387-92.
Seventeen children (ages ranging from 2 to 11 years at the onset of the study) were followed for 24.5 +/- 15 months (3 to 47 months) for a laryngeal papillomatosis requiring tracheotomy in 14. In 8 of the children evolution was low with a decrease or disappearance of relapses. On the contrary, 9 children, i.e. more than half the cases, presented with highly crippling disease, with frequent relapses of the laryngeal papillomas, extension of the lesions to the trachea, bronchi or even lungs, and local laryngeal complications (synechiae, sub-glottic stenosis). Medical anti-proliferative treatments had no effect. These children were submitted to iterative excisions. In 4 of them tracheotomy remained necessary after 3 years of evolution and their vital prognosis might become involved, either because of local complications or due to the extension of the lesions.
17名儿童（研究开始时年龄在2至11岁之间）接受了24.5±15个月（3至47个月）的随访，其中14名因喉乳头状瘤病需要进行气管切开术。8名儿童病情进展缓慢，复发次数减少或消失。相反，9名儿童，即超过半数的病例，患有严重致残性疾病，喉乳头状瘤频繁复发，病变扩展至气管、支气管甚至肺部，以及出现局部喉部并发症（粘连、声门下狭窄）。药物抗增殖治疗无效。这些儿童接受了反复切除手术。其中4名儿童在病情发展3年后仍需进行气管切开术，由于局部并发症或病变扩展，他们的生命预后可能受到影响。
