Nikolaidis E T, Trost D C, Buchholz C L, Wilkinson E J
Arch Pathol Lab Med. 1985 Jan;109(1):24-9.
Laryngeal papillomatosis is a disease that can lead to many surgical procedures, especially in children, and is potentially lethal. In this study, we reviewed 83 cases that yielded 902 separate laryngoscopy specimens to determine if any clinical or histologic findings were prognostic. "Juvenile" (n = 73) and "adult" (n = 10) cases were classified according to the number of separate lesions and the number of recurrences, but not necessarily according to age. Four prognostic indicators were constructed for the juvenile group and were analyzed by linear regression. Three new microscopic classifications were used: papillary, acanthomatous, and angiokeratotic. In juvenile cases, the last two categories appeared to be somewhat prognostic, along with several other factors. Some histopathologic findings contradicted classic descriptions. Differences in clinical manifestation and similarities in histopathology may suggest differential responses to the same causal agent.
喉乳头状瘤病是一种可能需要多次外科手术治疗的疾病，尤其是在儿童中，且具有潜在致命性。在本研究中，我们回顾了83例病例，这些病例共提供了902份独立的喉镜检查标本，以确定是否有任何临床或组织学发现具有预后意义。“青少年”（n = 73）和“成人”（n = 10）病例是根据独立病变的数量和复发次数进行分类的，而不一定是根据年龄。为青少年组构建了四个预后指标，并通过线性回归进行分析。使用了三种新的显微镜分类：乳头状、棘皮瘤样和血管角化瘤样。在青少年病例中，后两类以及其他几个因素似乎具有一定的预后意义。一些组织病理学发现与经典描述相矛盾。临床表现的差异和组织病理学的相似性可能表明对同一致病因子有不同的反应。
