Iranpour Maryam, Khodarahmi Ali, Khodarahmi Nima, Shafiee Mohammad, Malekpourafshar Reza, Nakhaee Nozar
Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Surgery, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
World J Plast Surg. 2020 Jan;9(1):48-54. doi: 10.29252/wjps.9.1.48.
Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of Montelukast have been observed to reduce ischemia/reperfusion injury in various organs due to angiogenic and anti-oxidant effects. The present study aimed to determine the role of Montelukast as medical delay of the flaps.
In this experimental study, 42 Wistar rats were divided into 3 equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) and Control Group (CG). In SDG, 8×3 cm rectangular randomized random skin flap was first surgically delayed at rats' back. The MDG received 10 mg/kg oral Montelukast via orogastric tube for 5 days as medical delay. In MDG and SDG flap, harvesting was undertaken after a delayed period, but there was not any delayed period in CG. After delayed period, a segment of the skin flap was biopsied for assessing angiogenesis. After 14 days, the photos were taken and the size of the necrotic area of the flap was measured.
A significant difference was observed between the mean survival and angiogenesis (=0.002). The same performance was reported between MDG and SDG, which were alike regarding survival and angiogenesis (>0.05); while there was a significant difference between the control and surgical groups, as well as control and medical groups (<0.05). Finally, the inflammation showed no significant difference (>0.05).
Regarding positive effects of Montelukast on survival and angiogenesis, it is recommended to be used as a medication for larger studies.
延迟现象可用于整形外科中皮瓣更好的血液供应。已观察到孟鲁司特因具有血管生成和抗氧化作用，可减轻各器官的缺血/再灌注损伤。本研究旨在确定孟鲁司特作为皮瓣药物延迟的作用。
在本实验研究中，将42只Wistar大鼠分为3组，每组数量相等。这些组分别为手术延迟组（SDG）、药物延迟组（MDG）和对照组（CG）。在SDG中，首先在大鼠背部对8×3厘米的矩形随机皮瓣进行手术延迟。MDG通过胃管口服10毫克/千克孟鲁司特，持续5天作为药物延迟。在MDG和SDG中，延迟一段时间后进行皮瓣采集，但CG中没有延迟期。延迟期后，取皮瓣的一部分进行活检以评估血管生成。14天后，拍照并测量皮瓣坏死区域的大小。
在平均存活和血管生成之间观察到显著差异（=0.002）。MDG和SDG之间表现相同，在存活和血管生成方面相似（>0.05）；而对照组与手术组之间以及对照组与药物组之间存在显著差异（<0.05）。最后，炎症无显著差异（>0.05）。
鉴于孟鲁司特对存活和血管生成的积极作用，建议将其用作进一步大型研究的药物。
