Jia Shuangmeng, Huang Jieshen, Lu Wuyan, Miao Yongen, Huang Kehua, Shi Chenzhang, Li Shuaijun, Huang Jiefeng
Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
School & Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, 200072, China.
J Pharm Anal. 2024 Jul;14(7):100948. doi: 10.1016/j.jpha.2024.02.002. Epub 2024 Feb 6.
Skin flaps are frequently employed in plastic and reconstructive surgery to address tissue defects. However, their low survival rates remain a challenge, attributed to vascular crisis and necrosis. Despite numerous studies investigating drugs to alleviate flap necrosis, a comprehensive analysis of the research trend in this critical area is lacking. To gain a deeper understanding of the current status, research focal points, and future trends in drugs aimed at enhancing flap survival, a thorough retrospective analysis is imperative. This study aims to employ bibliometric methods to scrutinize the evolution, mechanisms, and forthcoming trends of drugs targeting flap survival improvement. Using VOSviewer software, we quantitatively and visually depict 1) annual temporal trends in the number of documents and citations; 2) national/regional publications and their collaborations; 3) institutional and authors' contribution; 4) journal contribution and relevance; and 5) analysis of research hotspots and directions derived from keywords. Ultimately, we discussed the prospects and challenges of future advances and clinical translation of drugs designed to enhance skin flap survival. In conclusion, the field of pharmacology dedicated to improving skin flap survival is expanding, and this study aims to offer a fresh perspective to promote the advancement and clinical application of such drugs.
皮瓣在整形与重建外科中经常被用于解决组织缺损问题。然而，由于血管危象和坏死，其低存活率仍然是一个挑战。尽管有许多研究在探索缓解皮瓣坏死的药物，但在这一关键领域缺乏对研究趋势的全面分析。为了更深入地了解旨在提高皮瓣存活率的药物的现状、研究重点和未来趋势，进行全面的回顾性分析势在必行。本研究旨在采用文献计量学方法，审视旨在提高皮瓣存活率的药物的演变、作用机制和未来趋势。使用VOSviewer软件，我们定量并直观地描绘：1）文献数量和被引频次的年度时间趋势；2）国家/地区出版物及其合作情况；3）机构和作者的贡献；4）期刊贡献和相关性；5）基于关键词的研究热点和方向分析。最终，我们讨论了旨在提高皮瓣存活率的药物未来进展和临床转化的前景与挑战。总之，致力于提高皮瓣存活率的药理学领域正在不断扩展，本研究旨在提供一个新的视角，以促进此类药物的进步和临床应用。
