Snail、Galectin-3 和 IGF1R 在良恶性嗜铬细胞瘤和副神经节瘤鉴别诊断中的表达。
The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma.
机构信息
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Department of Endocrinology and Nephrology, Chongqing Emergency Medical Center (Chongqing the Fourth Hospital), No. 1 Jiankang Road, Yuzhong District, Chongqing 400014, China.
出版信息
Biomed Res Int. 2020 Feb 27;2020:4150735. doi: 10.1155/2020/4150735. eCollection 2020.
OBJECTIVE
The aim of this study was to investigate the expression of Snail, galectin-3, and IGF1R in benign and malignant pheochromocytoma and paraganglioma (PPGL) and explore their role in the diagnosis of malignant PPGL.
METHODS
We retrospectively collected and analyzed surgical tumor tissue from 226 patients initially diagnosed with PPGL who underwent surgery from Jan. 2009 to Jan. 2016 at West China Hospital, Sichuan University. We observed and quantified the expression of Snail, galectin-3, and IGF1R in paraffin-embedded samples by immunohistochemical staining.
RESULTS
The significant difference in survival time among the three groups (benign PHEO, benign PGL, and potentially malignant PPGL) was compared by Kaplan-Meier survival analysis. The positive staining of Snail, galectin-3, and IGF1R in the benign PHEO group was significantly lower than that in the other three groups ( < 0.001). The Kaplan-Meier survival plots indicated that the survival time of the patients with intense positive staining was significantly lower than that of the patients with weak positive staining.
CONCLUSION
The intense expression of Snail, galectin-3, and IGF1R may be valuable indicators for the diagnosis of malignant PPGL.
目的
本研究旨在探讨 Snail、半乳糖凝集素-3 和 IGF1R 在良性和恶性嗜铬细胞瘤和副神经节瘤（PPGL）中的表达，并探讨它们在恶性 PPGL 诊断中的作用。
方法
我们回顾性收集并分析了 2009 年 1 月至 2016 年 1 月期间在四川大学华西医院接受手术的 226 例最初诊断为 PPGL 的患者的手术肿瘤组织。我们通过免疫组织化学染色观察并量化石蜡包埋样本中 Snail、半乳糖凝集素-3 和 IGF1R 的表达。
结果
通过 Kaplan-Meier 生存分析比较三组（良性 PHEO、良性 PGL 和潜在恶性 PPGL）的生存时间差异。良性 PHEO 组中 Snail、半乳糖凝集素-3 和 IGF1R 的阳性染色明显低于其他三组（<0.001）。Kaplan-Meier 生存图表明，强阳性染色患者的生存时间明显低于弱阳性染色患者。
结论
Snail、半乳糖凝集素-3 和 IGF1R 的强烈表达可能是恶性 PPGL 诊断的有价值指标。
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