女性大学生抑郁症的心率变异性特征及代谢机制。
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.
机构信息
School of Sports, Shaanxi Normal University, Xi'an, China.
Xuefu Hospital, Shaanxi Normal University, Xi'an, China.
出版信息
Biomed Res Int. 2020 Feb 27;2020:5246350. doi: 10.1155/2020/5246350. eCollection 2020.
PURPOSE
To explore the effects of depression on cardiac autonomic nerve function and related metabolic pathways, the heart rate variability (HRV) and urinary differential metabolites were detected on the college students with depression.
METHODS
12 female freshmen with depression were filtered by the Beck Depression Inventory (BDI-II) and Self-rating Depression Scale (SDS). By wearing an HRV monitoring system, time domain indexes and frequency domain indexes were measured over 24 hours. Liquid chromatography-mass spectrometry (LC-MS) was used to detect their urinary differential metabolites. Differential metabolites were identified by principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA). The metabolic pathways related to these differential metabolites were analyzed by the MetPA database.
RESULTS
Stress time was significantly increased, and recovery time was markedly decreased in the depression group compared with the control group ( < 0.001). Standard deviation of the normal-to-normal R interval (SDNN), root mean square of the beat-to-beat differences (RMSSD), high frequency (HF), and low frequency (LF) were decreased significantly ( < 0.001). Standard deviation of the normal-to-normal R interval (SDNN), root mean square of the beat-to-beat differences (RMSSD), high frequency (HF), and low frequency (LF) were decreased significantly (.
CONCLUSION
Some autonomic nervous system disruption, high stress, and poor fatigue recovery were confirmed in college students with depression. The metabolic mechanism involved the disruption of coenzyme Q biosynthesis, glycine-serine-threonine metabolism, tyrosine metabolism, pyrimidine metabolism, and steroid metabolism under daily stress.
目的
探讨抑郁对心脏自主神经功能及相关代谢途径的影响，对抑郁大学生进行心率变异性（HRV）和尿差异代谢物检测。
方法
采用贝克抑郁量表（BDI-II）和抑郁自评量表（SDS）对 12 名抑郁的大一新生进行筛选。通过佩戴 HRV 监测系统，测量 24 小时内的时域指标和频域指标。采用液相色谱-质谱联用（LC-MS）检测其尿差异代谢物。采用主成分分析（PCA）和正交偏最小二乘判别分析（OPLS-DA）对差异代谢物进行鉴定。通过 MetPA 数据库分析与这些差异代谢物相关的代谢途径。
结果
与对照组相比，抑郁组的应激时间明显增加，恢复时间明显缩短（ < 0.001）。正常-正常 R 间期标准差（SDNN）、相邻 R 波间差值的均方根（RMSSD）、高频（HF）和低频（LF）显著降低（ < 0.001）。正常-正常 R 间期标准差（SDNN）、相邻 R 波间差值的均方根（RMSSD）、高频（HF）和低频（LF）显著降低（ < 0.001）。
结论
抑郁大学生存在一定程度的自主神经系统紊乱、应激水平升高和疲劳恢复能力差。在日常应激下，涉及辅酶 Q 生物合成、甘氨酸-丝氨酸-苏氨酸代谢、酪氨酸代谢、嘧啶代谢和类固醇代谢的代谢机制受到干扰。
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